Hiruma et al., Bone 2013
(Osteopetrosis) :
In addition, the ability of bone marrow derived monocytes/macrophages from the siglec-15 ( -/- ) mice to differentiate into osteoclasts was impaired, as determined in vitro by cellular tartrate-resistant acid phosphatase activity in response to the receptor activator of nuclear factor-?B ligand or tumor necrosis factor-a Trautwein et al., J Clin Invest 1998
:
An increase in TNF dependent nuclear expression of CCAAT/enhancer binding protein-beta ( C/EBP-beta ) /liver enriched activating protein (LAP) was detected after 1 h, whereas an increase in RNA expression was evident only after 4 h. C/EBP-beta/LAP expression returned to normal values before progression into the S-phase