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CAPN7 — CTNNB1
Text-mined interactions from Literome
Li et al., Proc Natl Acad Sci U S A 2002
:
Ca ( 2+ ) release from internal stores results in nuclear export and
calpain mediated degradation of
beta-catenin in the cytoplasm ... We conclude that Gq signaling promotes nuclear export and
calpain mediated degradation of
beta-catenin , which therefore contributes to the inhibition of Wnt/beta-catenin pathway
Abe et al., Neuron 2007
(Translocation, Genetic) :
Here, we show that, in hippocampal neurons, NMDA-receptor dependent activation of
calpain induced the cleavage of
beta-catenin at the N terminus, generating stable, truncated forms
Lee et al., J Neurochem 2008
:
Pharmacological studies and in vitro calpain-1 proteolysis confirmed that in the glutamate treated hippocampus,
calpain-1 mediated decrease of
beta-catenin could occur independently of GSK-3beta and of proteasome, and that GSK-3beta degradation is independent of calpain-1