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DDX58 — IL10

Text-mined interactions from Literome

Samanta et al., Oncogene 2008 (Burkitt Lymphoma) : Transfection of EBER expressing plasmid or in vitro synthesized EBER induced IL-10 in RIG-I expressing cell clones, and activation of IL-10 promoter by EBER was blocked by dominant negative RIG-I
Samanta et al., Cancer Sci 2010 (Burkitt Lymphoma) : In BL cells, EBERs activate RIG-I signaling and induce the expression of type-I IFNs and interferon stimulated genes ( ISGs ) through the activation of RIG-I substrates, nuclear factor-kappa B (NF-kappaB), and IFN regulatory factor 3 (IRF-3), and anti-inflamatory cytokine IL-10 through IRF-3 but not NF-kappaB signaling