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FOXO3 — PRKAA2

Text-mined interactions from Literome

Greer et al., J Biol Chem 2007 : Here, we find that AMPK directly regulates mammalian FOXO3 , a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity ... The regulation of FOXO3 by AMPK may play a crucial role in fine tuning gene expression programs that control energy balance and stress resistance in cells throughout life
Greer et al., Curr Biol 2007 : Lastly, we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites, suggesting a possible direct mechanism of regulation of FOXO/DAF-16 by AMPK
Nystrom et al., International journal of clinical and experimental medicine 2008 : Our data indicate FoxO mRNA expression is down-regulated by AMPK activation and energy depletion in cultured myotubes, but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions
Chiacchiera et al., Cell Death Differ 2009 (Colorectal Neoplasms) : Here, we show that p38alpha sustains the expression of HIF1alpha target genes encoding for glycolytic rate limiting enzymes, and that its inhibition causes a drastic decrease in ATP intracellular levels in CRCs. Prolonged inactivation of p38alpha triggers AMPK dependent nuclear localization of FoxO3A and subsequent activation of its target genes, leading to autophagy, cell cycle arrest and cell death
Li et al., Diabetes 2009 : AMPK activated FOXO3 by promoting its nuclear translocation
Greer et al., Ann N Y Acad Sci 2009 : AMPK phosphorylation enhances FoxO transcriptional activity, leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism
Ma et al., J Am Coll Cardiol 2009 (Disease Models, Animal...) : ALDH2 significantly attenuated ethanol induced decrease in Akt- and AMPK stimulated phosphorylation of Foxo3 at Thr32 and Ser413, respectively
Davila et al., Cell Death Differ 2012 : Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate ... The activation of AMPK reduced AKT activation, and led to dephosphorylation and nuclear translocation of FOXO3
Sato et al., Stem Cells Transl Med 2012 (Brain Neoplasms...) : Glioma Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK
Peserico et al., Cell Mol Life Sci 2013 : A novel AMPK dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels ... Here we report that glucose restriction triggers FoxO3A accumulation into mitochondria of fibroblasts and skeletal myotubes in an AMPK dependent manner
Vadlakonda et al., Frontiers in oncology 2013 : Depletion of energy leads to inactivation of mTORC1, activation of AMPK , FoxO , and promotes constitution of mTORC2 that leads to phosphorylation of Akt S473