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CXCL12 — JUN
Text-mined interactions from Literome
Cinatl et al., Int J Mol Med 2005
(Colonic Neoplasms...) :
High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of
AP-1 and NF-kappaB and
inhibited up-regulation of
CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels
Florin et al., J Cell Sci 2005
:
Increased keratinocyte proliferation by
JUN dependent expression of PTN and
SDF-1 in fibroblasts
Kremer et al., J Immunol 2007
:
IL-10 promoter activity was ablated by mutating two nonpolymorphic binding sites for the AP-1 transcription factor, and chromatin immunoprecipitation assays of primary human T cells revealed that
SDF-1 costimulation
enhances AP-1 binding to both of these sites
D'Aversa et al., J Neurosci Res 2008
(AIDS Dementia Complex...) :
Gel shift analyses demonstrated that NFkappaB and
AP-1 , but not C/EBPbeta,
mediate microglial
CXCL8 production
Sung et al., Circ Res 2009
(Atherosclerosis...) :
Inhibition of Sp1 and
AP-1 activations by specific siRNA
blocked the homocysteine induced
SDF-1 promoter activity and expression
Hsu et al., J Cell Physiol 2012
(Carcinoma, Hepatocellular...) :
Inhibition of Sp1 and
AP-1 activations by specific siRNAs
blocked the uPA induced
SDF-1 promoter activity and expression
Huang et al., J Cell Physiol 2012
(Colorectal Neoplasms...) :
Analysis of transcription factor binding using ELISA and chromatin immunoprecipitation assays revealed that
SDF-1 increased Sp1- and
AP-1-DNA binding activities in DLD-1 cells
Li et al., J Clin Endocrinol Metab 2011
(Inflammation...) :
In IL-1ß- or TNF-a stimulated first trimester decidual cells, NF?B inhibitor suppressed production of all six chemokines ;
JUN NH2-terminal kinase inhibitor
inhibited secretion of CCL2, CCL4, and CCL5 ; and MAPK kinase and p38 inhibitor decreased production of
CXCL8
Huang et al., J Cell Physiol 2013
(Colorectal Neoplasms...) :
Inhibition of NF-?B and
AP-1 activation
blocked the visfatin induced expression and activity of the
SDF-1 promoter