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JUN — NEUROD2
Text-mined interactions from Literome
Leppä et al., Mol Cell Biol 2001
(MAP Kinase Signaling System) :
We investigated how JNK and
c-Jun contribute to
neuronal differentiation , cell survival, and apoptosis
Feng et al., Mol Cell Biol 2002
(Neuroblastoma) :
Our results show that
c-Jun/AP-1 , through up-regulation of NCAM140,
plays an important role in both NGF induced
neuronal differentiation and resistance to apoptosis induced by NO in neuroblastoma cells ... Our results show that
c-Jun/AP-1 , through up-regulation of NCAM140,
plays an important role in both NGF induced
neuronal differentiation and resistance to apoptosis induced by NO in neuroblastoma cells
Yang et al., J Biol Chem 2008
(MAP Kinase Signaling System) :
Basic fibroblast growth factor induced
neuronal differentiation of mouse bone marrow stromal cells
requires FGFR-1, MAPK/ERK, and transcription factor
AP-1
Leppä et al., EMBO J 1998
:
Constitutively activated
c-Jun , which mimics the MAPK phosphorylated form of the protein, can
induce neuronal differentiation of PC12 cells independently of upstream signals ... Therefore, dual input of expression and phosphorylation of
c-Jun provided by the ERK pathway is
required to direct
neuronal differentiation in PC12 cells