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JUN — PRL
Text-mined interactions from Literome
Olazabal et al., Mol Endocrinol 2000
:
Using PRLR mutants and the PRLR short form, we have found that both homodimerization of PRLR wild type and the integrity of box-1 and C-distal tyrosine of PRLR intracellular domain are needed in
PRL induced proliferation and
AP-1 activation ... We found that Dex negatively regulates
PRL induced proliferation and
AP-1 site activation ... The
PRL induced
c-Jun of AP-1 transcriptional complex diminishes in the presence of Dex in a dose dependent manner ... Despite the fact that the regulation of the AP-1 site is complex, we found that
PRL activates the
c-Jun amino terminal kinase (JNK) , while glucocorticoid prevents this JNK activation
Carpenter et al., Endocrinology 2003
(Hyperprolactinemia) :
In study four, Western blot analyses indicated that
PRL increased levels of phosphorylated STATs 1 and 5, but not STAT 3, and phosphorylated ERK 1 and 2 MAPKs and
c-Jun N-terminal kinase/stress activated protein kinase proteins in explanted PND 28 ovine uteri
Farrow et al., Mol Endocrinol 2004
:
Previously, we have demonstrated that whereas
c-Jun inhibits pituitary-specific rat
prolactin ( rPRL ) promoter activity, expression of v-Jun stimulates the rPRL promoter in GH4 pituitary cells
Gutzman et al., Mol Endocrinol 2005
(Breast Neoplasms...) :
Here we demonstrate that
PRL and E2 cooperatively
enhance the activity of
AP-1 in MCF-7 derived cells
Romero-Prado et al., J Cell Biochem 2006
:
In the absence of FBS and in the
presence of insulin or
prolactin , cells show cytoskeletal organization and an
AP-1 transcription site activity resembling proliferative osteochondrocytes while cells in the presence of dexamethasone and added prolactin or TGF-beta resembled differentiated osteoblasts
Andria et al., Biochem Biophys Res Commun 2007
:
Prolactin expression is
induced in Jurkat T-cells by beta-catenin LEF-1,
AP-1 and cAMP
Gutzman et al., Oncogene 2007
(Neoplasms) :
Stat5 activation inhibits
prolactin induced
AP-1 activity : distinct prolactin initiated signals in tumorigenesis dependent on cell context ... Further, reduction of Stat5 protein with siRNA in T47D cells, which contain elevated Stat5, increased
PRL induced
AP-1 signals, transcripts for the AP-1 target, matrix metalloproteinase-2 and associated invasive behavior
Conrad et al., Mol Cell Biol 1994
:
In contrast, we show that intact
c-Jun expression
inhibited the Ras induced activation of the
prolactin promoter, defining it as a negative regulator of this pathway, whereas c-Jun was able to enhance the Ras activation of an AP-1-driven promoter in GH4 cells
Caccavelli et al., Mol Endocrinol 1998
:
Transcription factor AP1 is
involved in basal and okadaic acid stimulated activity of the human
PRL promoter