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JUN — TANK
Text-mined interactions from Literome
Leonardi et al., J Biol Chem 2000
:
TRAF2 is
required for TNF induced activation of
c-Jun N-terminal kinase/stress activated protein kinase ( JNK/SAPK ), and TRAF2 can also mediate activation of NF-kappaB
Li et al., Nature 2002
:
TRAF2 is
required for TNF-alpha mediated activation of
c-Jun N-terminal kinase (JNK) , contributes to activation of NF-kappaB, and mediates anti-apoptotic signals,
Lee et al., J Biochem Mol Biol 2002
:
The
AP1 activation by
TRAF2 , TRAF5, and TRAF6 was also greatly suppressed by the dominant negative TAK1
Park et al., J Biol Chem 2003
(Hepatitis C) :
Because
TRAF2 is
required for the activation of both NF-kappaB and
c-Jun N-terminal kinase (JNK) , we investigated HCV NS5A protein for its potential capacity to modulate TRAF2 mediated JNK activity
Ishizawa et al., Biol Cell 2006
:
xFADD and xRIP1 synergistically
induced the activation of
AP-1 and NF-kappaB, both of which were partially mediated by
TRAF2 ( tumour-necrosis-factor-receptor associated factor 2 ) and TAK1 ( transforming-growth-factor-beta activated kinase 1 )
Blackwell et al., Mol Cell Biol 2009
(Lymphoma) :
Notably,
TRAF2 phosphorylation
increased both basal and inducible
c-Jun and NF-kappaB activities and rendered cells resistant to stress induced apoptosis
Lee et al., J Cell Physiol 2010
(MAP Kinase Signaling System) :
Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the
TNFR1/TRAF2/PKCalpha dependent
JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways
Zhang et al., Mol Biol Cell 2011
:
Tumor necrosis factor a (TNF-a) receptor associated factor 2 (
TRAF2 )
regulates activation of the c-Jun N-terminal kinase
(JNK)/c-Jun and the inhibitor of ?B kinase ( IKK ) /nuclear factor ?B ( NF-?B ) signaling cascades in response to TNF-a stimulation