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IFNG — IRF7
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kano et al., Biochem Biophys Res Commun 1999
:
Taken together,
IRF-1 mediates
IFN-gamma signaling into primary hepatocytes for cell cycle arrest via p53 expression and for apoptosis
Green et al., Leukemia 1999
(Chromosome Deletion...) :
Unexpectedly, all primary acute promyelocytic leukemia ( APL ) samples lacked IRF-1 protein and most exhibited accelerated exon skipping ; furthermore,
IRF-1 could not be
induced by
IFNgamma or all-trans retinoic acid ( ATRA ) which both induce IRF-1 in the NB4 APL cell line
Jarosinski et al., J Neuroimmunol 2002
:
MHC class I gene promoter activity in astrocytes was controlled entirely through a single enhancer, the
MHC-IRF-E , to which IRF-1 bound in
response to
IFN-gamma in wild type but not in IRF-1 ( -/- ) mouse astrocytes
Andrews et al., J Biol Chem 2002
:
Importantly,
IFN-gamma mediated induction of
IRF-7 and MxA was attenuated in the BRCA1 mutant cell line HCC1937, an effect that was rescued following reconstitution of exogenous wild type BRCA1 in these cells
Sheikh et al., Cardiovasc Res 2005
(Arteriosclerosis) :
Northern blotting showed that lysoPC transiently and dose-dependently inhibited the
IFN gamma induced accumulation of IP-10, Mig and I-Tac but not p48,
interferon regulatory factor-1 and guanidine binding protein-1
Shi et al., Int J Biochem Cell Biol 2006
(Breast Neoplasms...) :
Both treatments induced USF-1 and
IRF binding complexes to promoter IV but only
IFNgamma induced the binding of 435-Lung2 nuclear proteins to an ARE-1 site at the promoter III
Bennett et al., Blood 2006
(Inflammation...) :
Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents
IFNgamma/tumor necrosis factor alpha (TNFalpha)
induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation,
IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Buckley et al., Mol Cancer Res 2007
:
Using an Affymetrix U95A microarray,
IRF-7 was identified as a BRCA1 transcriptional target and was also shown to be synergistically up-regulated by BRCA1 specifically in the
presence of
IFN-gamma , coincident with the synergistic induction of apoptosis ... We also show that the
induction of
IRF-7 by BRCA1 and
IFN-gamma is dependent on the type I IFNs, IFN-alpha and IFN-beta
Schedel et al., Am J Respir Crit Care Med 2008
(Genetic Predisposition to Disease...) :
Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding,
IRF-1 gene expression, and
IFN-gamma regulation
Shultz et al., J Interferon Cytokine Res 2009
:
Roles of IKK-beta,
IRF1 , and p65 in the activation of chemokine genes by
interferon-gamma
Faure et al., J Biol Chem 1999
:
The decrease of
LPS/IFN-gamma induced IRF-1 promoter activity,
IRF-1 synthesis, and IRF-1 activation, by PDTC, genistein, PD98059, and SB 203580, could explained in part the inhibition of the NOS-2 induction by these compounds