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SMAD4 — SUMO1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: SMAD4 — SUMO1 Kagey et al., EMBO J 2005*
• IRef Bind_translation Interaction: SMAD4 — SUMO1 (experimental interaction detection) Kagey et al., EMBO J 2005*
• IRef Biogrid Interaction: SMAD4 — SUMO1 (physical association, affinity chromatography technology) Lin et al., J Biol Chem 2003*
• IRef Biogrid Interaction: SMAD4 — SUMO1 (physical association, affinity chromatography technology) Lin et al., J Biol Chem 2003*
• IRef Biogrid Interaction: SMAD4 — SUMO1 (physical association, affinity chromatography technology) Ohshima et al., J Biol Chem 2003*
• IRef Biogrid Interaction: SMAD4 — SUMO1 (physical association, affinity chromatography technology) Lee et al., J Biol Chem 2003*

Text-mined interactions from Literome

Lin et al., J Biol Chem 2003 : SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4 ... We found that SUMO-1 overexpression strongly increases Smad4 levels, while inhibition of SUMOylation by small interfering RNA ( siRNA ) -mediated knockdown of the E2 enzyme Ubc9 reduces endogenous Smad4 levels ... Concomitantly, SUMO-1 overexpression enhances and Ubc9 knockdown reduces levels of intranuclear Smad4 , growth inhibitory response, as well as transcriptional responses to TGF-beta ... Concomitantly, SUMO-1 overexpression enhances and Ubc9 knockdown reduces levels of intranuclear Smad4 , growth inhibitory response, as well as transcriptional responses to TGF-beta
Chang et al., J Biol Chem 2005 : Daxx mediates the small ubiquitin-like modifier dependent transcriptional repression of Smad4