◀ Back to RELA
RELA — RIPK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Meylan et al., Nat Immunol 2004
:
In the absence of RIP1, TLR3 mediated signals activating NF-kappa B, but not the kinase JNK or interferon-beta, were abolished, suggesting that
RIP1 mediates Trif induced
NF-kappa B activation
Youn et al., J Immunol 2005
:
Furthermore, resveratrol inhibited the kinase activity of TANK binding kinase 1 and the
NF-kappaB activation
induced by
RIP1 in RAW264.7 cells
Sullivan et al., J Immunol 2007
:
Furthermore, zebrafish TICAM1 does not interact with zebrafish TNFR associated factor 6, thus
NF-kappaB activation is
dependent upon its interaction with
receptor interacting protein 1
Wright et al., Dev Cell 2007
:
We further show that CYLD negatively
regulates a ubiquitin dependent
NF-kappaB activator,
RIP1
Wang et al., Biochemistry 2008
:
Finally, we showed that CK1alpha enhanced
RIP1 mediated
NF-kappaB activation
Park et al., Cancer Res 2009
(Brain Neoplasms...) :
The death domain kinase
receptor interacting protein 1 (RIP1) plays a key role in
nuclear factor-kappaB (NF-kappaB) activation and also activates the PI3K-Akt pathway through unknown mechanisms ... However, unlike other signals that regulate mTOR activity without affecting its level,
RIP1 negatively regulates mTOR transcription via a
NF-kappaB dependent mechanism
Cho et al., Cell 2009
(Necrosis...) :
The kinase
RIP1 is crucial for programmed necrosis, but also
mediates activation of the prosurvival transcription factor
NF-kappaB
Wong et al., Cell Death Differ 2010
:
RIPK1 is not
essential for TNFR1 induced activation of
NF-kappaB