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ELAVL1 — SIRT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ELAVL1-SIRT1 (decreases) Abdelmohsen et al., Mol Cell 2007*
  Evidence: the amount of SIRT1 mRNA that is constitutively bound to HuR was substantially reduced by the H2O2 treatment, as monitored by RTqPCR

Text-mined interactions from Literome

Abdelmohsen et al., Mol Cell 2007 : Phosphorylation of HuR by Chk2 regulates SIRT1 expression ... Here, we report that HuR associated with the 3 ' untranslated region of the mRNA encoding the longevity and stress-response protein SIRT1, stabilized the SIRT1 mRNA, and increased SIRT1 expression levels ... Our findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes
Yamakuchi et al., Frontiers in physiology 2012 : The background of SIRT1 and miRNAs will be summarized, followed by the mechanism by which several key miRNAs alter SIRT1 levels, and how the RBP HuR regulates SIRT1