◀ Back to PLCG1

CD2 — PLCG1

Text-mined interactions from Literome

Martelli et al., Blood 2000 : Using Jurkat cell lines deficient in ZAP70/Syk ( P116 ) or LAT ( ANJ3 ) expression, CD2 dependent PLCgamma-1 and SLP-76 tyrosine phosphorylation required expression both of ZAP70 or Syk and of LAT
Kanner et al., J Immunol 1992 : CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling ... We show that stimulation of CD2 receptors on T cells caused tyrosine phosphorylation of PLC gamma 1 ... Cross linking of CD2 with CD3 receptors augmented the phosphorylation of PLC gamma 1 on tyrosine, whereas ligation of the CD45 tyrosine phosphatase with CD2 receptors prevented PLC gamma 1 tyrosine phosphorylation ... CD3 receptor modulation potently down-regulated CD2 induced PLC gamma 1 tyrosine phosphorylation and calcium mobilization ... In contrast, PMA or ionomycin treatment did not alter CD2 stimulated tyrosine phosphorylation of PLC gamma 1 , suggesting that tyrosine kinase inhibition by CD3 receptor modulation was not caused by signaling events downstream of PLC gamma 1
Yang et al., J Immunol 2006 : The overexpression of CD2BP1 selectively attenuates phospholipase Cgamma1 , ERK1/2, and p38 phosphorylation without abrogating CD2 independent TCR stimulation
Ryu et al., J Biol Chem 1987 : Cd2+ selectively inhibits PLC-II with a I0.5 value of 5 microM
Hubert et al., J Immunol 1996 : By contrast, CD2 induces PLCgamma-1 tyrosine phosphorylation as efficiently as CD3, with a correlated inositol phosphate production and intracellular calcium increase, and even a higher production of IL-2