Middlemas et al., J Biol Chem 1994
:
Since phosphorylation of Tyr-783 and Tyr-1254 results in activation of phospholipase C-gamma 1, we predict that neurotrophin-3 leads to activation of phospholipase C-gamma 1 following binding to TrkB in Rat-2 cells
Widmer et al., J Neurochem 1993
:
The present study analyzed the effects of brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on phosphorylation of PLC-gamma 1 in primary cultures of embryonic rat brain cells ... BDNF and NT-3 stimulated the phosphorylation of PLC-gamma 1 , followed by hydrolysis of PI ... K-252b, a compound known to inhibit selectively neutrophin actions by interfering with the phosphorylation of trk-type neutrophin receptors, prevented the BDNF- and NT-3 stimulated phosphorylation of PLC-gamma 1