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TBK1 — TLR4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
TLR4
→
TBK1
(reaction)
Fitzgerald et al., Nat Immunol 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Panne et al., J Biol Chem 2007, Larabi et al., Cell reports 2013
-
Reactome Reaction:
TLR4
→
TBK1
(indirect_complex)
Fitzgerald et al., Nat Immunol 2003, Hemmi et al., J Exp Med 2004, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Larabi et al., Cell reports 2013
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sankar et al., Cell Signal 2006
:
Although the literature to date suggests that IKK-i and
TBK1 play redundant roles in TLR3 and
TLR4 signaling, recent data suggest that there may be subtle differences in the signaling pathways affected by these kinases
Clark et al., Proc Natl Acad Sci U S A 2011
:
Here we show that
TBK1 and IKKe are also
activated by
TLR ligands that signal via MyD88
Jakus et al., J Nutr Biochem 2013
:
Resveratrol was suggested to inhibit
Toll-like receptor (TLR)4 mediated activation of nuclear factor-?B ( NF-?B ) and Toll/interleukin-1 receptor domain containing adaptor inducing interferon-ß ( TRIF ) - (
TANK ) -binding kinase 1 , but the myeloid differentiation primary response gene 88-tumor necrosis factor receptor associated factor 6 ( TRAF6 ) pathway is not involved in this effect
Lin et al., J Immunol 2012
:
Studies revealed that 3-MA can, through inhibition of Akt as a result of class I PI3K interference, positively regulate p38, JNK, and p65, but negatively regulate
TANK binding kinase 1 and IFN regulatory factor 3
mediated by
TLR4
Lin et al., Science signaling 2013
(Inflammation) :
In contrast, Syk-deficient macrophages exhibited decreased
TLR4 dependent activation of
TBK1 signaling and production of type I IFNs