Gene interactions and pathways from curated databases and text-mining

◀ Back to INSR

INSR — SHC3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: SHC3 → INSR (directlyIncreases, SHC3 Activity)
    Evidence: insulin stimulates the mitogen-activated protein (MAP) kinase extracellular signalregulated kinase (ERK) (Fig. 2). This pathway involves the tyrosine phosphorylation of IRS proteins and/or Shc, which in turn interact with the adapter protein Grb2, recruiting the Son-of-sevenless (SOS) exchange protein to the plasma membrane for activation of Ras.
  • KEGG Insulin signaling pathway: INSR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
  • WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway: INSR → SHC2/SHC3/SHC1 (activation)
  • WikiPathways Insulin Signaling: INSR → SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 (activation)