Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
SHC3
→
INSR
(directlyIncreases, SHC3 Activity)
Evidence: insulin stimulates the mitogen-activated protein (MAP) kinase extracellular signalregulated kinase (ERK) (Fig. 2). This pathway involves the tyrosine phosphorylation of IRS proteins and/or Shc, which in turn interact with the adapter protein Grb2, recruiting the Son-of-sevenless (SOS) exchange protein to the plasma membrane for activation of Ras.