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IL2 — NFATC2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → IL2 (IL2) (transcription, inhibits) Iacobelli et al., J Immunol 2000
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → IL2 (IL2) (transcription, inhibits) Yang et al., J Biol Chem 2000
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1/FOXP3 complex (NFATC2-FOXP3) → IL2 (IL2) (transcription, inhibits) Wu et al., Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → IL2 (IL2) (transcription, inhibits) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL2 (IL2) (transcription, activates) Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: NFATC2 — IL2 (unknown, -) Nguyen et al., Mol Immunol 2010*
• IRef Innatedb Interaction: NFATC2 — IL2 (unknown, -) Decker et al., Nucleic Acids Res 2003
• STRING interaction: IL2 — NFATC2 (interaction, mapped from grid kegg_pathways mint dip)
• STRING interaction: NFATC2 — IL2 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Yang et al., J Biol Chem 2006 (Carcinoma, Hepatocellular...) : We report that interleukin-1 or tumor necrosis factor-alpha increases expression of and activates NFATc2
Kyttaris et al., J Immunol 2007 (Lupus Erythematosus, Systemic) : Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus
Karwot et al., J Allergy Clin Immunol 2008 (Bronchial Hyperreactivity...) : Taken together, our results suggest that NFATc2 expression in long lived memory CD8+ T cells controls IL-2 and IFN-gamma production in lung CD8+ T cells, which then limits TH17 and TH2 development in the airways during allergen challenge
Nguyen et al., Mol Immunol 2010 : These studies show that a previously unidentified interaction between human NFATc2 and cJun is necessary for synergistic activation of IL-2 transcription in T cells
McCaffrey et al., J Biol Chem 1994 (Cell Transformation, Neoplastic) : The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation
Rao et al., Immunol Today 1994 : Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium dependent transcription of other cytokine genes in several types of immune-system cells
Maggirwar et al., Mol Cell Biol 1997 : Transient-transfection studies reveal that expression of either NF-ATp or the p50-RelA NF-kappaB heterodimer leads to the potent transactivation of both the CD28RE enhancer and the intact IL-2 promoter in mitogen stimulated cells ... Together, these results suggest that activation of IL-2 gene transcription by the TCR- and CD28 mediated signals involves the interaction of CD28RE with NF-ATp and various NF-kappaB/Rel transcription factors