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IL2 — NFKBIA

Text-mined interactions from Literome

Ponnappan et al., Cell Immunol 1999 : This failure to degrade IkappaBalpha may underlie both the observed decrease in NFkappaB induction and the IL-2 receptor expression in TNF treated T cells during aging
Iacobelli et al., J Immunol 1999 : The current study clearly demonstrates that IL-2 does not induce I kappa B alpha degradation or NF-kappa B activation in primary human T cells that respond to IL-2 by entering the cell cycle and avoiding apoptosis
Alpert et al., J Biol Chem 1999 : In addition, sorbitol and H ( 2 ) O ( 2 ) blocked TNF induced but not interleukin-1 induced IkappaBalpha phosphorylation, whereas arsenite inhibited IkappaBalpha phosphorylation induced by TNF and interleukin-1
Soloff et al., Mol Hum Reprod 2004 : We were unable to detect any significant differences between primary and immortalized cells in signal pathways such as epidermal growth factor stimulated epidermal growth factor receptor phosphorylation, insulin stimulated Akt phosphorylation, oxytocin and lysophosphatidic acid stimulated extracellular signal regulated kinase 1 and 2 phosphorylation, myosin light chain phosphorylation, and interleukin-1 induction of IkappaBalpha degradation
Newton et al., J Pharmacol Exp Ther 2007 (Pulmonary Disease, Chronic Obstructive) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF) alpha increased phosphorylation of IkappaBalpha , and this was followed by loss of IkappaBalpha, induction of NF-kappaB DNA binding, and the induction of NF-kappaB dependent transcription
McKean et al., J Exp Med 1994 : Other receptor initiated events including induction of I kappa B alpha phosphorylation, expression of c-jun and junB mRNA, and costimulatory effects on IL-2 synthesis also are altered by IL-1 receptor desensitization
Xie et al., Mol Immunol 1997 : Interestingly, the DEX mediated IkappaBalpha induction was completely inhibited by IL-2 , but not IL-4, in Th1 cells, while the reverse profile was seen in Th2 cells