◀ Back to CD79A
CD79A — SMAD3
Text-mined interactions from Literome
Park et al., Eur J Immunol 2001
(Lymphoma, B-Cell) :
Smad3 and Smad4
mediate transforming growth factor-beta1 induced
IgA expression in murine B lymphocytes ... Finally, in the presence of TGF-beta1, overexpression of
Smad3/4 selectively
increases both surface
IgA expression and IgA production
Park et al., Eur J Immunol 2003
:
We have shown previously that
Smad3 and Smad4
mediate TGF-beta1 induced
IgA expression ... Overexpression of Runx3 and
Smad3/4 increased
IgA secretion by both cell types in response to TGF-beta1
McKarns et al., Int Immunopharmacol 2003
:
Concentration dependent bifunctional effect of TGF-beta 1 on immunoglobulin production : a
role for
Smad3 in
IgA production in vitro ... Moreover, stimulation of IgA by TGF-beta(1) was abrogated in LPS sensitized Smad3 ( Exon8-/- ) splenocytes suggesting an additional
role for
Smad3 in regulating
IgA production in vitro
Park et al., Eur J Immunol 2005
:
Smad3/4 , Runx3 and p300 mediate TGF-beta1 induced germ-line ( GL ) alpha transcription
leading to
IgA expression
Li et al., Int Urol Nephrol 2010
(Glomerulonephritis, IGA) :
When these findings are considered together, it is of interest to explore how Arkadia and
Smad signaling
affect TGF-ß ( 1 ) -induced
IgA expression in IgAN