Gene interactions and pathways from curated databases and text-mining

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FOS — TRAF6

Text-mined interactions from Literome

Funakoshi et al., Int Immunopharmacol 2001 : These observations were prominent particularly in the TRAF6 transfection system, in which overexpression of wild type TRAF6 augmented the IL-1 mediated NF-kappa B and AP-1 activation, while dominant negative TRAF6 construct ( delta TRAF6 ) suppressed these activation ... Namely, LY294002 inhibited TRAF6 mediated IL-1 induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6 induced AP-1 activation but not NF-kappa B activation
Funakoshi-Tago et al., Eur J Biochem 2003 : TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway ... We found that IL-1 mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6)
Wang et al., Nat Immunol 2006 : Formation of the beta-arrestin-TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappaB and AP-1