◀ Back to CASP4
CASP4 — IL1A
Text-mined interactions from Literome
Wright et al., J Biol Chem 1999
:
In addition, IFN-gamma/TNF-alpha and
IL-1alpha/IFN-gamma/TNF-alpha stimulate activation of
caspase-8 and caspase-3, which IL-13 pretreatment was able to partially inhibit and delay
Lemonnier et al., Am J Pathol 2001
(Acrocephalosyndactylia...) :
Thus, the Apert S252W FGFR-2 mutation promotes apoptosis in human osteoblasts through activation of protein kinase C, overexpression of
IL-1 and Fas,
activation of
caspase-8 , and increased Bax/Bcl-2 levels, leading to increased effector caspases and DNA fragmentation
Martinon et al., Mol Cell 2002
(Inflammation) :
Generation of
Interleukin (IL)-1beta via cleavage of its proform
requires the activity of
caspase-1 ( and caspase-11 in mice ), but the mechanism involved in the activation of the proinflammatory caspases remains elusive
Schaub et al., Circ Res 2003
:
This indicates that calpains are not required for activation of caspases and that
caspase activation is not
sufficient for
IL-1alpha release and MCP-1 upregulation
Fortunato et al., Placenta 2003
:
When compared to control,
IL-1 beta
increased caspase 2, 3, 8 and 9 activities, whereas IL-6 treated membranes did not exhibit a significant change
Ubol et al., Microbiol Immunol 2005
(Disease Models, Animal...) :
The first is immune mediated death which may operate through the receptor-ligand pathway
activated by
caspase-1 and the pro-inflammatory cytokine,
IL-1beta
Dinarello et al., Semin Nephrol 2007
(Inflammation...) :
IL-18 is a member of the IL-1 family
; IL-1beta and IL-18 are related closely, and both
require the intracellular cysteine protease
caspase-1 for biological activity
Miggin et al., Proc Natl Acad Sci U S A 2007
:
However, we found that Mal was cleaved by caspase-1 and that inhibition of
caspase-1 activity
blocked TLR2- and TLR4 mediated NF-kappaB and p38 MAP kinase activation but not
IL-1 or TLR7 signaling, which are Mal independent
Gustavsson et al., Retina 2008
(Diabetes Mellitus, Experimental...) :
Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ),
IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes
induced increased expression of
caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Lee et al., Nature 2009
(Alstrom Syndrome...) :
The non-canonical secretion of
IL1alpha is
induced by a p38-MAPK mediated upregulation of NALP3 ( also known as NLRP3 ), leading to inflammasome assembly and
caspase 1 activation
Franchi et al., J Immunol 2009
(Inflammation) :
In addition to TNF-alpha,
IL-1alpha and IL-1beta
promoted caspase-1 activation via Nlrp3 in response to ATP
Dinarello et al., Expert Rev Clin Immunol 2005
:
IL-18 is a member of the IL-1 family
; IL-1beta and IL-18 are closely related, and both
require the intracellular cysteine protease
caspase-1 for biologic activity
Joosten et al., Arthritis Rheum 2010
(Arthritis, Gouty...) :
Thereafter, production of
interleukin-1ß (IL-1ß) and
activation of
caspase 1 were determined
Maron-Gutierrez et al., Eur Respir J 2011
(Pulmonary Fibrosis...) :
Nevertheless,
caspase-3 ,
IL-1ß , IL-1a, IL-1RN and TGF-ß mRNA expression
diminished after cell therapy
Rolli et al., Crit Care 2010
(Systemic Inflammatory Response Syndrome) :
Plasma TNFa, IL-6 and MIP-2 disclosed a transient peak, whereas
IL-1ß and soluble TREM-1 steadily increased over 6 h. Flagellin also
triggered a marked cleavage of
caspase-3 and PARP in the intestine, pointing to its ability to promote significant apoptosis in this organ
Jayaraman et al., J Exp Med 2010
(Inflammation...) :
Tim3-Gal9 interaction leads to macrophage activation and stimulates bactericidal activity by inducing
caspase-1 dependent
IL-1ß secretion
Miao et al., Nat Immunol 2010
(Salmonella Infections) :
Macrophages mediate crucial innate immune responses via
caspase-1 dependent processing and secretion of
interleukin 1ß (IL-1ß) and IL-18
Shushanov et al., Bull Exp Biol Med 2010
:
Proinflammatory cytokine
IL-1ß specifically
stimulates caspase-3/7 in vitro in RGC-5 rat eye retinal neurons ... Insulin and insulin-like growth factor-1 and their combination inhibit
caspase-3/7 activation in these cells,
induced by removal of the serum from culture medium and/or by
IL-1ß treatment
Oosting et al., Eur J Immunol 2011
(Lyme Disease) :
The
caspase-1 dependent cytokine
IL-1ß has been linked to the generation of IL-17 producing T cells, whereas caspase-1 mediated IL-18 is crucial for IFN-? production
Allam et al., J Immunol 2011
(Peritonitis) :
All four antibiotics
required the NLRP3 inflammasome, the adaptor ASC, and
caspase-1 activation to secrete
IL-1ß , a process that depended on potassium efflux but was independent of P2X7 receptor
Sauter et al., Cancer Biol Ther 2011
:
The release of
IL-1ß required the expression of ASC,
caspase-1 , and NLRP3, demonstrating that doxorubicin and daunorubicin induced inflammation is mediated by the NLRP3 inflammasome
Zheng et al., PLoS Pathog 2011
:
As compared to other YopJ isoforms, YopJ ( KIM ) causes increased apoptosis,
caspase-1 activation , and secretion of
IL-1ß in Yersinia infected macrophages
Han et al., Exp Dermatol 2011
(Dermatitis, Atopic...) :
The increased enzymatic activity of
caspase-1 in the dorsal skin of the kanamycin administered mice
increased the mRNA expressions of
IL-1ß and IL-18
Shi et al., Anesth Analg 2011
(Pain) :
Previously, we observed in the rat tibia fracture model of CRPS that activation of
caspase-1 containing NALP1 inflammasomes was
required for
interleukin (IL)-1ß production in keratinocytes, and that administration of an IL-1 receptor antagonist ( anakinra ) reduced the fracture induced hindpaw mechanical allodynia ... Finally, we determined whether neuropeptide stimulated
IL-1ß production
required activation of
caspase-1 and cathepsin B ... Inhibition of
caspase-1 activity using the selective inhibitor Ac-YVAD-CHO reduced SP and, less effectively, CGRP
induced increases in
IL-1ß production in REK cells
Eitel et al., Frontiers in microbiology 2010
:
Inflammasomes regulate
caspase-1 dependent production of the key inflammatory cytokines
IL-1ß and IL-18 as well as pyroptotic cell death in L. monocytogenes infected cells
Ather et al., J Immunol 2011
(Disease Models, Animal...) :
Activation of the NLRP3 inflammasome by microbial and environmental stimuli can enable the
caspase-1 dependent processing and secretion of
IL-1ß
Marshall et al., Vet Res 2011
:
Toxoplasma gondii peroxiredoxin promotes altered macrophage function,
caspase-1 dependent
IL-1ß secretion enhances parasite replication
Khameneh et al., PloS one 2011
(Shock, Septic) :
In addition, we show that expression of Rab39a, a GTPase required for
caspase-1 dependent
IL-1ß secretion is greatly augmented by LPS and GM-CSF co-stimulation suggesting a potential GM-CSF contribution in enhancing IL-1ß exocytosis
Gross et al., Immunol Rev 2011
:
An inflammasome is a multiprotein complex that serves as a platform for caspase-1 activation and
caspase-1 dependent proteolytic maturation and secretion of
interleukin-1ß (IL-1ß)
Komune et al., J Virol 2011
:
We demonstrate that measles virus ( MV ) infection induces
caspase-1 dependent
IL-1ß secretion in the human macrophage-like cell line THP-1
Fettelschoss et al., Proc Natl Acad Sci U S A 2011
(Inflammation) :
Surface IL-1a requires NF-?B activation only, whereas secretion of mature
IL-1a requires additional activation of the inflammasome and
caspase-1
Lichtnekert et al., PloS one 2011
(Glomerulonephritis...) :
Anti-GBM glomerulonephritis
involves IL-1 but is independent of NLRP3/ASC inflammasome mediated activation of
caspase-1
Luheshi et al., Eur J Immunol 2012
(Peritonitis) :
IL-1ß secretion
requires the protease
caspase-1 , which is activated following recruitment to inflammasomes
Lunov et al., ACS Nano 2011
:
The PS-NH ( 2 ) -mediated proinflammatory macrophage activation could be antagonized by the radical scavenger N-acetyl-L-cysteine, which prevented mitochondrial damage,
caspase-1 activation , and the subsequent release of
IL-1ß
Costa et al., J Immunol 2012
(Streptococcal Infections) :
IL-1ß release required both pro-IL-1ß transcription and
caspase-1 dependent proteolytic cleavage of intracellular
pro-IL-1ß
Moore et al., PloS one 2012
(Inflammation...) :
Small interfering RNA mediated C/EBPd silencing exacerbated
IL-1ß+IFN-? induced
caspase 9 and 3 cleavage and apoptosis in these cells
Zambetti et al., Immunol Res 2012
(Disease Models, Animal...) :
The Nucleotide binding oligomerization domain, Leucine-rich Repeat and Pyrin domain containing ( NLRP ) family and corresponding inflammasomes are important intracellular sensors of microbial pathogens and stress signals that promote
caspase-1 mediated release of
IL-1ß and IL-18
Gross et al., Immunity 2012
(Calcium Signaling...) :
Inflammasome-caspase-1 dependent release of
IL-1a and IL-1ß was independent of caspase-1 catalytic activity, defining a mode of action for caspase-1
Levinsohn et al., PLoS Pathog 2012
:
Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome,
caspase-1 activation , rapid programmed cell death ( pyroptosis ) and maturation of
IL-1ß and IL-18
Benoit et al., J Immunol 2012
:
Finally, C1q decreased procaspase-1 cleavage and
caspase-1 dependent cleavage of
IL-1ß suggesting a potent inhibitory effect of C1q on inflammasome activation
Lee et al., PloS one 2012
(Acute Disease...) :
We also showed that ATP-P2X(7)R signaling regulates inflammasome activation as inhibition or deficiency of P2X(7)R as well as
caspase-1 significantly
reduced IL-1ß secretion
Chen et al., PloS one 2012
:
Results indicated that viable, but not heat killed, M. kansasii induced
caspase-1 dependent
IL-1ß secretion in macrophages
Zheng et al., PloS one 2012
(Necrosis...) :
In addition, cytotoxicity and
IL-1ß secretion were not
reduced in the presence of a
caspase-8 inhibitor, or in B-cell lymphoma 2 (Bcl-2) associated X protein ( Bax ) /Bcl-2 homologous antagonist/killer (Bak) knockout macrophages, showing that YopJ ( KIM ) -mediated cell death and caspase-1 activation occur independent of mitochondrial directed apoptosis
Jacobs et al., J Leukoc Biol 2012
(Virus Diseases) :
Upon pathogen infection, some NLR proteins form large complexes, called inflammasomes, which activate
caspase-1 and
induce the production of active
IL-1ß and IL-18
Nasti et al., Photochem Photobiol 2012
(Inflammation) :
Normal skin contains only low levels of inactive precursor forms of
IL-1ß and IL-18, which
require caspase 1-mediated proteolysis for their maturation and secretion
Koo et al., PloS one 2012
(Scrub Typhus) :
Furthermore, Orientia stimulated secretion of
IL-1ß and
activation of
caspase-1 are ASC- and caspase-1- dependent since IL-1ß production was impaired in Asc- and caspase-1-deficient macrophages but not in Nlrp3-, Nlrc4- and Aim2-deficient macrophages
Kavathas et al., Mucosal Immunol 2013
:
In this study, we report that Ct-induced trophoblast IL-1ß secretion is associated with the transcription of IL-1ß mRNA, the translation and processing of
pro-IL-1ß , and the
activation of
caspase-1
Kim et al., Food Chem Toxicol 2012
(Rhinitis, Allergic, Perennial) :
In activated human mast cells, BS significantly inhibited the production of
IL-1ß and thymic stromal lymphopoietin and
activation of
caspase-1
Huang et al., PloS one 2012
:
In addition,
caspase-1 was activated and
involved in proteolytic cleavage and secretion of
IL-1ß in AbM treated macrophages
Galle et al., PloS one 2012
(Acute Disease...) :
However, macrophages from dSTY infected mice died by pro-inflammatory necrosis characterized by membrane permeabilization and
caspase-1 mediated
IL-1ß production, whereas macrophages from dSTY/dPopB infected mice died by apoptosis, which is characterized by annexin V positive staining of the cell membrane and caspase-3 activation
Burton et al., J Orthop Res 2013
(Disease Models, Animal...) :
The role of caspase-1 in a mouse calvarial model of particle mediated osteolysis was assessed using µCT. Phagocytosis of PMMA particles induces
caspase-1 dependent release of
IL-1ß from human monocytes and mouse macrophages
Li et al., Cytokine 2012
:
Direct treatment of THP-1 cells with Chry caused cell death,
activation of
caspase-1 and release of
IL-1ß , while the addition of caspase-1 inhibitor, Z-YVAD-FMK, reduced IL-1ß, suggesting that Chry activated the caspase-1 mediated Nod-like receptor protein 3 (NLRP3) inflammasome ; by comparison, LIB had less effects on all of these parameters
Savage et al., Frontiers in immunology 2012
:
The release of
IL-1ß is
regulated by the protease
caspase-1 , and its activating complex, the inflammasome
Szabo et al., Dig Dis 2012
(Inflammation...) :
The inflammasome, a multiprotein complex, senses endogenous danger molecules to result in
caspase-1 mediated cleavage of
IL-1ß
Yazdi et al., Ann Rheum Dis 2013
(Inflammation) :
Depending on the type of NLRP3 agonist, release of
IL-1a is
NLRP3-inflammasome/caspase-1 dependent or independent, but in both cases IL-1a processing depends on calpain protease activity
Peng et al., Small 2013
(Inflammation) :
While the particles are phagocytosed by macrophages in a size independent manner, only large particles or NP aggregates in the micrometer range induce cellular responses that include production of mitochondrial reactive oxygen species,
caspase-1 activation , and secretion of
interleukin-1ß (IL-1ß)
Gillette et al., J Biol Chem 2013
(Burkholderia Infections) :
Transfection of
caspase-1 into airway epithelial cells
restored their ability to secrete
IL-1ß following B. cenocepacia infection, suggesting that a deficiency in caspase-1 is responsible, at least in part, for the attenuated IL-1ß secretion
Pejnovic et al., Diabetes 2013
(Body Weight...) :
In vitro stimulation of LGALS3 ( -/- ) peritoneal macrophages with lipopolysaccharide (LPS) and saturated fatty acid palmitate caused increased
caspase-1 dependent
IL-1ß production and increased phosphorylation of NF-?B p65 compared with WT cells
Grant et al., Frontiers in immunology 2013
:
The secretion of bioactive
IL-1ß is predominantly
controlled by activation of
caspase-1 through assembly of a multiprotein scaffold, `` inflammasome '' that is composed of NLRP3 ( nucleotide binding domain, leucine-rich containing family, pyrin domain-containing-3 ) ASC ( apoptosis associated speck-like protein containing a CARD ) and procaspase-1
Jayaraman et al., J Immunol 2013
:
IL-1ß directly augments TNF signaling in macrophages through the upregulation of TNF secretion and TNFR1 cell surface expression, and
results in activation of
caspase-3
Rajamäki et al., J Biol Chem 2013
(Acidosis) :
Acidic medium triggered pH-dependent secretion of
IL-1ß and
activation of
caspase-1 via a mechanism involving potassium efflux from the cells
Lippai et al., J Leukoc Biol 2013
:
IL-1ß production
requires caspase-1 activation by inflammasomes-multiprotein complexes that are assembled in response to danger signals
Lin et al., PloS one 2013
(Plaque, Atherosclerotic) :
In in-vitro experiments showed that ox-LDL induced
caspase-1 activation and this activation was
required for ox-LDL induced macrophages lysis,
IL-1ß and IL-18 production as well as DNA fragmentation
Eigenbrod et al., J Immunol 2013
:
Bacterial RNA is an important trigger of inflammasome activation, resulting in
caspase-1 dependent cleavage of
pro-IL-1ß into the active form
Lefèvre et al., Immunity 2013
(Leishmaniasis, Visceral) :
Dectin-1 and MR were crucial for the microbicidal response as indicated by the fact that they activated Syk-p47phox and arachidonic acid ( AA ) -NADPH oxidase signaling pathways, respectively, needed for ROS production and also triggered Syk coupled signaling for
caspase-1 induced
IL-1ß secretion
Ansari et al., J Virol 2013
:
We observed evidence of inflammasome activation, such as the
activation of
caspase-1 and cleavage of
pro-IL-1ß , -IL-18, and -IL-33, in EBV latency I Raji cells, latency II NPC C666-1 cells, and latency III lymphoblastoid cell lines ( LCL )
Piper et al., PloS one 2013
:
Release of these cytokines was not dependent on cell death, and only
IL-1ß and IL-18 release was
dependent on
caspase-1 catalytic activity
Casson et al., PLoS Pathog 2013
:
Unlike IL-1ß,
IL-1a secretion does not
require caspase-1 ... Instead,
caspase-11 activation is
required for both
IL-1a secretion and cell death in response to the activity of these secretion systems ... Interestingly, whereas caspase-11 promotes IL-1ß release in response to the type IV secretion system through the NLRP3/ASC inflammasome,
caspase-11 dependent release of
IL-1a is independent of both the NAIP5/NLRC4 and NLRP3/ASC inflammasomes as well as TRIF and type I interferon signaling
Lage et al., Proc Natl Acad Sci U S A 2013
(Salmonella Infections) :
Here, we found that although NLRC4, ASC, and
caspase-1 are
required for
IL-1ß secretion in response to cytosolic flagellin, cell death, nevertheless, occurs in the absence of these molecules
Lippai et al., PloS one 2013
(Alcoholism...) :
Alcohol induced miR-155 regulates TNFa and MCP1 expression but not
caspase dependent
IL-1ß increase in neuroinflammation
Silva et al., J Immunol 2013
(Chagas Disease...) :
Following pathogen infection, NLRs form large molecular platforms, termed inflammasomes, which activate
caspase-1 and
induce the production of active
IL-1ß and IL-18
Jaeschke et al., J Immunol 1998
(Disease Models, Animal...) :
Furthermore, only murine TNF-alpha but not
IL-1alphabeta increased
caspase activity and apoptosis