◀ Back to IRF6
IRF6 — PTK6
Text-mined interactions from Literome
Pedron et al., FEMS Immunol Med Microbiol 2000
:
This particular response of BMC to
LPS required the activation of
protein tyrosine kinase and p38 MAP kinase
Ternisien et al., Thromb Haemost 1995
:
As it has been established that LPS and PMA activate protein tyrosine kinase ( PTK ) in monocytes, we studied the
role of
PTK in
LPS and PMA induction of TF by human blood monocytes ... Both
LPS- and PMA induced TF activity was
inhibited in a concentration dependent manner by the
protein tyrosine kinase-specific inhibitors herbimycin A and genistein
Geng et al., J Immunol 1993
:
Both
PTK inhibitors also
reduced the
LPS activation of nuclear factor-kappa B (NF-kappa B), which is a transcription factor involved in the expression of cytokine genes such as IL-6 and TNF-alpha ... In summary, these findings suggest that protein kinase C and protein kinase A appear to have selective effects in the LPS induction of cytokines, whereas
PTK is
required for
LPS induction of a broad spectrum of cytokines and NF-kappa B activation in monocytes
Meisel et al., Eur J Immunol 1996
:
LPS induced TNF-alpha and IL-10 expression
requires early activation of
protein tyrosine kinases ( PTK )
Adamson et al., Cell adhesion and communication 1996
:
However when
PTK inhibitors were present during both agonist activation ( 2h ) and subsequent expression of E-selectin after removal of agonist ( 4h ) the PTK inhibitors
resulted in a dose dependent reduction in both IL-1 alpha and
LPS stimulated E-selectin expression ( IC50 = 50M ) ... Moreover when PTK inhibitors were only incubated with cells for the 4h after cytokine or LPS activation of cells,
PTK inhibitors
resulted in a more effective dose dependent reduction in IL-1 alpha or
LPS stimulated E-selectin expression ( IC50 = 10M )
Liang et al., Biochem Biophys Res Commun 1997
:
These results suggest that PTK is critical for hepatocyte NO synthesis, and DMSO inhibited NO synthesis may be associated with prevention of
LPS/CM induced
PTK activation in hepatocytes