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FADD — TNF

Pathways - manually collected, often from reviews:

• BioCarta nf-kb signaling pathway: TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta nf-kb signaling pathway: TNF-alpha (TNF) → TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: TNF-alpha (TNF) → TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) → TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) (modification, collaborate)
  
• BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → FADD (modification, activates)
• BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → FADD/Caspase 8 complex (CASP8-FADD) (modification, activates)
  
• BioCarta ceramide signaling pathway: FADD/Caspase 8 complex (CASP8-FADD) → TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TRAF1 → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: RAIDD (CRADD) → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: SODD (BAG4) → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → cIAP2 (BIRC3) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → ASK1 (MAP3K5) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TRADD (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TRAF2 (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → Caspase 2 (CASP2) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → FADD (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → RIP (RIPK1) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A) → FADD (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, activates)
  Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: RAIDD (CRADD) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FADD (FADD) → TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FADD (FADD) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: ASK1 (MAP3K5) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TRAF1 (TRAF1) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: cIAP2 (BIRC3) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: BAG4 (BAG4) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: Caspase 2 (CASP2) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → TRADD (TRADD) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → RIP (RIPK1) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → TRAF2 (TRAF2) (modification, collaborate)
• NCI Pathway Database TNF receptor signaling pathway : FADD (FADD) → sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) (modification, collaborate)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : FADD (FADD) → sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF) (modification, collaborate)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : FADD (FADD) → sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) (modification, collaborate)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF) (modification, collaborate)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Ceramide signaling pathway: FADD/Caspase 8 complex (CASP8-FADD) → TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) (modification, collaborate)
  Boldin et al., Cell 1996, Muzio et al., Cell 1996
  Evidence: assay
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → NIK (MAP3K14) (modification, activates) Malinin et al., Nature 1997
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → Caspase 8 (CASP8) (modification, activates) Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → Caspase 8 (CASP8) (modification, activates) Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF) (modification, activates)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Hatano et al., J Biol Chem 2000 : Expression of either crmA or a dominant negative mutant of the Fas associated death domain protein prevented TNFalpha- and Fas mediated apoptosis
Ramakrishnan et al., Mol Cell 2011 : Sam68 is also found as a part of the TNF induced cytoplasmic caspase-8-FADD complex