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SIRT1 — TAT

Text-mined interactions from Literome

Zhang et al., J Cell Biochem 2010 : Tat transactivating activity is controlled by nicotinamide adenine nucleotide ( + ) ( NAD ( + ) ) -dependent deacetylase sirtuin 1 (SIRT1) ... Thus, the effect of Nampt on Tat regulated SIRT activity was studied in Hela-CD4-beta-gal ( MAGI ) cells ... Further investigation revealed that Tat induced inhibition of SIRT1 activity was potentiated in Nampt-knockdown by Nampt siRNA compared to treatment with Tat alone ... Altogether, these results indicate that Nampt is critical in the regulation of Tat induced inhibition of SIRT1 activity and long terminal repeat ( LTR ) transactivation
Chen et al., Int J Biochem Cell Biol 2013 : Tat 's transactivating activity is controlled by sirtuin 1 (SIRT1) that connects HIV transcription with the metabolic state of the cell