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CTGF — SMAD9

Text-mined interactions from Literome

Phanish et al., Nephron. Experimental nephrology 2005 (Fibrosis...) : TGF-beta1 induced connective tissue growth factor ( CCN2 ) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling
Arnott et al., Bone 2008 : To investigate the involvement of the TGF-beta1 response element (TRE) and the SMAD binding element ( SBE ) in CTGF induction, we cloned the rat CTGF proximal promoter ( -787 to +1 ) containing the TRE and SBE motifs into a pGL3-Luciferase reporter construct
Li et al., Phytomedicine 2010 (Hyperplasia) : Furthermore, the augmented expression of CTGF and TIMP-2 in HG-exposed cells was mediated by Akt activation and TGF-beta/Smad signaling through PKCbeta2-responsive signaling pathways
Lee et al., Cell Tissue Res 2012 (Glomerulonephritis, Membranous...) : Furthermore, activated TGF-ß/Smad signaling by podocytes may induce connective tissue growth factor and vascular endothelial growth factor overexpression, which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis
Kim et al., Mol Cell Biochem 2012 (Burns...) : In the presence of inhibitors of PI3K, Src, Smad , or reactive oxygen species, the effect of NRG1 on CTGF expression decreased significantly
Tang et al., PloS one 2012 (Liver Cirrhosis) : The hepatoprotective effects of AA on fibrosis were associated with upregulation of hepatic Smad7, an inhibitor of TGF-beta signaling, thereby blocking upregulation of TGF-beta1 and CTGF and the activation of TGF-beta/Smad signaling
Zuehlke et al., Cell communication and signaling : CCS 2012 : Only part of these cells also synthesized CTGF indicating that Smad activation alone was not sufficient for CTGF induction