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EPHB2 — SPR

Text-mined interactions from Literome

Yamaguchi et al., Cancer Chemother Pharmacol 2005 (Glioblastoma) : Using either the epidermal growth factor receptor (EGFR) kinase inhibitor, AG 1478, or a small interfering RNA ( siRNA ) directed against human EGFR, we found that transactivation of EGFR by SPR is only marginally involved in SP-dependent ERK1/2 phosphorylation
Yamaguchi et al., Brain Tumor Pathol 2005 (Astrocytoma) : At the molecular level, stimulation of SPR in human U373 MG glioblastoma cells results in phosphorylation of mitogen activated protein kinases ERK1/2 ... Examination of the underlying mechanism reveals that SPR mediates ERK1/2 phosphorylation in a calcium dependent manner ... Surprisingly, blockade of epidermal growth factor receptor (EGFR), which is transactivated by SPR, has a minimal effect on SPR mediated ERK1/2 phosphorylation ... However, SPR mediated ERK1/2 phosphorylation is significantly reduced by the Src kinase inhibitor PP2