Gottfried et al., EMBO J 2004
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ARTS leads to decreased XIAP protein levels and caspase activation
Edison et al., Cell Death Differ 2012
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The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo ... Here, we show that ARTS initiates caspase activation upstream of MOMP ... We also show that ARTS induced caspase activation leads to cleavage of the pro-apoptotic Bcl-2 family protein Bid, known to promote MOMP