Gene interactions and pathways from curated databases and text-mining

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APOE — INS

Text-mined interactions from Literome

Vergès et al., Diabetes Metab 2001 (Diabetes Mellitus, Type 2...) : Indeed, insulin stimulates apoB/E receptor ( LDL-receptor ) activity and enhances LDL degradation via the LDL-receptor pathway
Yue et al., J Biol Chem 2004 : Neither insulin nor a peroxisome proliferator activated receptor ( PPAR) alpha agonist regulated adipocyte apoE gene expression
Titiov et al., Vestn Ross Akad Med Nauk 2005 : INS initiated the synthesis of apoE and active receptor uptake of FA by cells in the form of triglycerides through apoE/B- 100 receptor endocytosis
Fishel et al., Arch Neurol 2005 (Hyperinsulinism...) : Increased inflammation was modulated by insulin induced changes in CSF levels of norepinephrine and apolipoprotein E ( both P < .05 )
Lei et al., Biochem Biophys Res Commun 2008 : We found that ApoE4 can strongly bind to amylin, and insulin can hardly inhibit amylin-ApoE binding
Du et al., Neurosci Lett 2009 : We report here that, in comparison with ApoE2 and ApoE3, ApoE4 significantly reduces levels of insulin degrading enzyme (IDE) , which is responsible for the cellular clearance of Abeta in neurons
Liu et al., J Neurosci Methods 2012 : Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats