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CAPN3 — GRIN2B
Text-mined interactions from Literome
Simpkins et al., J Neurosci 2003
(Brain Ischemia) :
An inhibitor of
calpain blocked both the decrease of intact
NR2B and the increase of the low molecular weight form, whereas neither caspase nor cathepsin inhibitors had an effect on these events
Dong et al., J Neurosci 2004
:
We examined the ability of postsynaptic density-95 (PSD-95) protein to alter the
calpain mediated cleavage of NR2A and
NR2B
DeRidder et al., Neurobiol Dis 2006
(Brain Injuries...) :
At moderate injury levels, both caspase-3 and
calpain activation was
attenuated by blocking
NR2B containing NMDARs prior to stretch or by blocking all NMDARs prior to stretch injury
Goñi-Oliver et al., J Biol Chem 2007
(Alzheimer Disease) :
This truncation was blocked by the calpain inhibitor calpeptin, at the same concentration at which it inhibits
calpain mediated cleavage of
NMDAR-2B and of p35 ( the regulatory subunit of CDK5 )
Sato et al., J Neurosci 2008
(Alzheimer Disease...) :
Expression of recombinant TTBK1 in primary mouse cortical neurons significantly downregulated
NR2B in a CDK5- and
calpain dependent manner
Gladding et al., Hum Mol Genet 2012
(Disease Models, Animal...) :
Moreover, combined
calpain inhibition and STEP inactivation
reduced extrasynaptic, while increasing synaptic
GluN2B expression in the YAC128 striatum