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PGD — TNF

Text-mined interactions from Literome

Davidson et al., J Steroid Biochem Mol Biol 2008 : TNF-alpha increased PGD2 levels which were enhanced by 7beta-OH-EPIA
Brenneis et al., J Biol Chem 2011 (Disease Models, Animal...) : Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced tumor necrosis factor a (TNFa) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
Leal-Berumen et al., J Immunol 1995 : In contrast, constitutive production of TNF-alpha was inhibited by PGE1 and PGE2, but not by PGD2
Vedin et al., Prostaglandins Leukot Essent Fatty Acids 1996 : To investigate possible mechanisms for this we determined effects of PGD2 , PGJ2 and two PGJ2 metabolites delta 12-PGJ2 and 15-deoxy-delta 12, delta 14 PGJ2 on tumor necrosis factor-alpha (TNF-alpha) release from blood monocytes in vitro
Meja et al., Br J Pharmacol 1997 : 7. Since PGD2 and 17-phenyl-omega-trinor PGE2 ( EP1-agonist ) did not suppress TNF alpha generation, the EP1/EP2/DP-receptor antagonist, AH 6809, was employed to assess if EP2-receptors mediated the inhibitory effect of PGE2