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IPO7 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Marchenko et al., Cell Death Differ 2010
(Adenocarcinoma...) :
Stress mediated nuclear stabilization of
p53 is
regulated by ubiquitination and
importin-alpha3 binding ... Conversely, stress induced accumulation of non ubiquitinated
p53 in the cytoplasm
promotes interaction with
importin-alpha3 and rapid import
Golomb et al., Mol Cell 2012
:
We report that transcription of the ß-karyopherin genes
importin 7 (IPO7) and exportin 1 ( XPO1 ), and several additional nuclear import receptors, is
regulated positively by c-Myc and negatively by
p53 ...
Activation of
p53 by
IPO7 knockdown has distinct features of ribosomal biogenesis stress, with increased binding of Mdm2 to ribosomal proteins L5 and L11 ( RPL5 and RPL11 )