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Hanley et al., J Invest Dermatol 2000 : Oxysterols induce differentiation in human keratinocytes and increase Ap-1 dependent involucrin transcription ... These data suggest that oxysterols induce keratinocyte differentiation, in part through increased AP-1 dependent transcription of the involucrin gene, an effect that may be mediated by liver X-activated receptor
Tran et al., Biochem J 2004 (Calcium Signaling) : Kinase induced changes in involucrin promoter activity directly resulted from changes in AP-1 protein expression
Alvarez-Salas et al., Int J Oncol 2005 : This study shows that overexpression of either YY1 or c-Jun represses transcription of the human involucrin gene in multiplying keratinocytes ... Transient overexpression and site directed mutagenesis experiments of the involucrin 5'-non coding region ( 5'-NCR ) confirmed that YY1 and c-Jun repress involucrin transcription
Crish et al., J Invest Dermatol 2006 : These studies suggest that AP1 , Sp1, and C/EBP transcription factors are required for appropriate differentiation dependent involucrin expression, and that the mechanism of regulation is similar in most surface epithelia
Dai et al., J Dermatol Sci 2008 : These results suggest that PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25 ( OH ) 2D3 induced keratinocyte differentiation
Han et al., PloS one 2012 : Involucrin is a marker of keratinocyte differentiation that is expressed in the suprabasal epidermis and this expression requires AP1 factor interaction at the AP1-5 site in the promoter