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E2F1 — FGFR1
Text-mined interactions from Literome
Parakati et al., Dev Dyn 2005
:
Upon overexpression,
E2F4 repressed
FGFR1 promoter activity in a dose dependent manner in myoblasts and Drosophila SL2 cells, and mutation of the E2F4 binding site increased FGFR1 promoter activity and reduced E2F4 mediated repression
Kanai et al., Gene 2009
:
Transcriptional
regulation of human
fibroblast growth factor receptor 1 by
E2F-1 ... Furthermore, we show that the expression of human
FGFR 1 is
regulated by
E2F-1 ... Characterization of the human FGFR 1 promoter demonstrated that two non-consensus E2F binding sequences at positions +4 to +22 and +25 to +43 relative to our identified transcriptional initiation site in the human FGFR 1 gene were critical for
E2F-1 mediated transactivation of human
FGFR 1 promoter ... Mutations of these sites completely abolished the
response of human
FGFR 1 promoter to
E2F-1 as well as E2F-1 binding in electrophoretic mobility-shift assays ... Moreover, human
FGFR 1 protein expression was
up-regulated by the overexpression of
E2F-1 , but down-regulated by the overexpression of pRB in situ, suggesting that the expression of human FGFR 1 is regulated by the pRB/E2F pathway