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Lu et al., Cancer Res 2011
(Nasopharyngeal Neoplasms) :
Mechanistic investigations revealed that miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the cyclin dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21 ( CIP1 ) in an EZH2 dependent manner
Maki et al., Anticancer Res 2012
(Mesothelioma...) :
miR-34b/c inhibited expression of cyclin-D1, cyclin dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation
Giglio et al., J Cell Physiol 2013
:
In this report we describe that miR-24 directly targets p27 ( Kip1 ) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis