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CD36 — IL10
Text-mined interactions from Literome
Rubic et al., Cardiovasc Res 2006
(Atherosclerosis) :
Picomolar
IL-10 suppressed basal and peroxisome proliferator activated receptor gamma ( PPARgamma ) -stimulated transcription of the scavenger receptor
CD36 due to reduced PPARgamma protein expression
Parsons et al., Endocr Metab Immune Disord Drug Targets 2008
(Inflammation) :
A recent publication demonstrates that induction of
IL-10 by apoptotic cells is largely
dependent upon the interaction between apoptotic cells and
CD36 , the receptor on monocytes and macrophages for apoptotic cells ... This provides a direct mechanistic link between
CD36 engagement and
IL-10 induction , opening up new possibilities for using CD36 ligands, agents that increase CD36 expression or a combination of both to modulate inflammation and treat, or even prevent, an important set of chronic disorders