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CSN2 — SKP1
Text-mined interactions from Literome
Cope et al., Cell 2003
:
Here, we summarize what is known about CSN, and discuss hypotheses for how
CSN promotes the activity of
SCF ubiquitin ligases
Carrabino et al., Brain Res Gene Expr Patterns 2004
:
The
CSN controls the function of the
SCF ubiquitin-ligase complex through an enzymatic activity that removes the small ubiquitin-like molecule NEDD8 from the cullin component of the SCF and that requires subunit 5 of the CSN ( JAB1/CSN5 )
Enchev et al., Cell reports 2012
:
Taken together, the results provide a model for how reciprocal regulation sensitizes
CSN to the SCF assembly state and
inhibits a catalytically competent
SCF until a ubiquitination substrate drives its own degradation by displacing CSN, thereby promoting cullin neddylation and substrate ubiquitination
Huang et al., PloS one 2013
:
Unexpectedly however, csn3-3 plants are not defective in either the
CSN mediated deneddylation of CUL1 or in
SCF ( TIR1 ) -mediated degradation of Aux/IAA proteins