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CD44 — CTNNB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Voutilainen et al., J Clin Pathol 2006
(Ovarian Neoplasms) :
The correlation between nuclear beta-catenin and CD44 indicates that
beta-catenin may
regulate the transcription of
CD44 in epithelial ovarian cancer
Bourguignon et al., J Biol Chem 2009
(Breast Neoplasms) :
Hyaluronan mediated
CD44 interaction with p300 and SIRT1
regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells ... Further analyses indicate that activation of SIRT1 ( deacetylase ) by resveratrol ( a natural antioxidant ) induces SIRT1-p300 association and acetyltransferase inactivation, leading to deacetylation of
HA/CD44 induced
beta-catenin and NFkappaB-p65, inhibition of beta-catenin-T-cell factor/lymphocyte enhancer factor and NFkappaB-specific transcriptional activation, and the impairment of MDR1 and Bcl-x ( L ) gene expression
Han et al., Med Sci Monit 2012
(Colonic Neoplasms...) :
siRNA mediated down-regulation of
beta-catenin elevated the E-cadherin expression but
reduced the MMP-7 and
CD44v6 expressions, which increased the adhesion between LoVo cells but decreased the adhesion of LoVo cells to fibronectin