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IRF1 — IRF3

Pathways - manually collected, often from reviews:

• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  

Text-mined interactions from Literome

Xi et al., Oncogene 1999 (Pancreatic Neoplasms) : Here we report that the human CIITA Type IV promoter IRF-E binds IRF-1 and can be activated by exogenous expression of IRF-1
Xi et al., Mol Immunol 2003 : Off-rate experiments revealed that the IRF-2/IRF-E complex was more stable than the IRF-1/IRF-E complex and that the affinity of IRF-1 for the IRF-E was increased when IRF-1 co-occupied the IRF-E with IRF-2
Hemmi et al., J Exp Med 2004 (Virus Diseases) : Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA ) induce phosphorylation of interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction
Guo et al., J Immunol 2005 : IRF-2 constitutively binds to the two ISRE/IRF-E sites at the DRR, while IRF-1 and STAT1 are induced to bind to the two ISRE/IRF-E sites and the ISRE/IRF-E1, respectively, only after IFN-beta treatment
Bibeau-Poirier et al., J Immunol 2006 (Virus Diseases) : In agreement with this observation, IRF-3 is recruited to Cullin1 following virus infection and overexpression of a dominant negative mutant of Cullin1 significantly inhibits the degradation of IRF-3 observed in infected cells
Daffis et al., J Virol 2008 (Viremia...) : In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules ( RIG-I, MDA5, and TLR-3 ) and induction of interferon regulatory factor IRF-3 dependent gene transcription
Pan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 (Leukemia, Promyelocytic, Acute) : It is concluded that during ATRA induced APL cell differentiation, IRF-1 is first upregulated by ATRA, and then IRF-1 increases the protein levels of IRF-9 and STAT2 with the downregulation of C/EBPalpha
Sweeney et al., J Immunol 2010 (Arthritis, Rheumatoid) : IRF3 regulates IFN stimulated response element ( ISRE ) promoter activity as well as IFN-beta, IRF5 , IRF7, RANTES, IFN-inducible protein-10, MCP-1, and MIP1alpha gene expression in response to poly ( I-C )
Kondo et al., Hokkaido Igaku Zasshi 1996 (Leukemia...) : Functional analysis showed that IRF-BP inhibited DNA binding and transcriptional activity of IRF-1
Schafer et al., J Biol Chem 1998 : Surprisingly, activation of the IFNA4 gene promoter by virus and IRF-1 in these cells was inhibited by IRF-3