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NOS3 — ROCK2

Text-mined interactions from Literome

Ming et al., Mol Cell Biol 2002 : Using adenovirus mediated gene transfer in human umbilical vein endothelial cells ( HUVECs ), we show here that both active RhoA and ROCK not only downregulate eNOS gene expression as reported previously but also inhibit eNOS phosphorylation at Ser-1177 and cellular NO production with concomitant suppression of PKB activation
Barandier et al., Biochem Biophys Res Commun 2003 : We showed that expression of constitutively active RhoA ( Rho63 ) or ROCK ( CAT ) suppressed eNOS gene expression ... Similarly, suppression of eNOS expression and activation of ROCK , but not RhoA by thrombin were prevented by PKC inhibition or depletion
Jin et al., Neurosci Lett 2006 : Hypoxia induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression
Zhou et al., Curr Pharm Des 2009 (Atherosclerosis...) : While increased ROCK activity is associated with endothelial dysfunction, cerebral ischemia, coronary vasospasms and metabolic syndrome, the inhibition of ROCK by statins or selective ROCK inhibitors leads to up-regulation of endothelial nitric oxide synthase (eNOS) , decreased vascular inflammation, and reduced atherosclerotic plaque formation
Hassona et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : The activation of Rho/ROCK led to the inhibition of endothelial nitric oxide synthase expression ( 39 + or - 5.4 % ; P < 0.05 ) and phosphorylation ( 35 + or - 4.5 % ; P < 0.05 ) but also an increase in myosin light chain 20 phosphorylation ( 372 %, P < 0.05 )
Wu et al., Int J Immunopathol Pharmacol 2011 : Human H441 cells were grown in hypoxia for 24-72 h. KMUP-1 ( 1, 10, 100 microM ) arrested cells at the G0/G1 phase of the cell cycle, reduced cell survival and migration, increased p21/p27, restored eNOS , increased soluble guanylate cyclase ( sGC ) and PKG and inhibited Rho kinase II ( ROCK-II )
Ramseyer et al., Hypertension 2012 : Inhibition of ROCK with 10 µmol/L of H-1152 blocked TNF-a induced decreases in NOS3 expression by 66 ± 15 % ( P < 0.001 )