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INS — IRF6
Text-mined interactions from Literome
Sugita et al., Am J Physiol Endocrinol Metab 2002
(Hyperglycemia...) :
Inducible nitric oxide synthase plays a role in
LPS induced hyperglycemia and
insulin resistance
Soop et al., Am J Physiol Endocrinol Metab 2002
(Diabetes Mellitus, Type 2...) :
In vitro studies showed no modulation of
LPS stimulated IL-6 or TNF-alpha production by glucose,
insulin , or leptin at physiologically relevant concentrations
Vives-Pi et al., Clin Exp Immunol 2003
:
In vitro experiments using rat islets ( also positive for CD14 by RT-PCR ) and HP62 cells showed that
LPS regulates glucose dependent
insulin secretion and induces inflammatory cytokines [interleukin (IL)-1alpha, IL-6 and tumour necrosis factor (TNF)-alpha ]
Doherty et al., Cytokine 1992
:
Adrenocorticotrophic hormone ( ACTH ) and
insulin increased supernatant levels of TNF bioactivity in
response to
LPS , while each decreased available TNF-alpha gene transcripts
Orellana et al., Am J Physiol Endocrinol Metab 2007
(Endotoxemia...) :
In the presence of fasting
insulin and amino acids,
LPS reduced protein synthesis in longissimus dorsi ( LD ) and gastrocnemius muscles and increased protein synthesis in the diaphragm, but had no effect in masseter and heart muscles
Cao et al., J Nutr 2008
(Inflammation) :
TTP expression is reduced in fats of obese people with metabolic syndrome and brains of suicide victims and is
induced by
insulin and cinnamon polyphenol extract (CPE) in adipocytes, by
lipopolysaccharide (LPS) in macrophages, and by green tea polyphenol extract in rats
Kiely et al., J Endocrinol 2009
:
We have now extended this area of research and have determined the
effects of
LPS on cell viability, insulin secretion,
insulin signalling and metabolism in a clonal beta-cell line ... Incubation of BRIN-BD11 cells for 24 h in the presence of increasing concentrations of the TLR4 ligand LPS significantly decreased chronic ( 24 h )
insulin secretion from 1.09+/-0.19 to 0.76+/-0.18 microg insulin/mg protein in the
presence of 100 ng/ml
LPS ( P < 0.05 )
Pang et al., Neuroscience 2010
:
Furthermore, microglia derived
insulin-like growth factor-1 (IGF-1) and ciliary neurotrophic factor (CNTF) were significantly
suppressed by
LPS , and exogenous IGF-1 and CNTF synergistically protected OLs from death induced by LPS treated microglia conditioned medium, indicating that a deficiency in trophic support may also be involved in OL death
Wilden et al., Proc Natl Acad Sci U S A 1990
:
The phosphotransferase activity of the dephospho form of both the IR and
IRF1146 toward exogenous substrates was
stimulated 3- to 4-fold by
insulin
Amyot et al., PloS one 2012
:
LPS repression of insulin, PDX-1 and MafA expression, as well as its
inhibition of
insulin secretion, were not observed in islets from TLR4-deficient mice
Buhl et al., J Clin Endocrinol Metab 2013
(Insulin Resistance) :
Leg blood flows, phenylalanine, lactate kinetics, cytokines, and intramyocellular
insulin signaling were not
affected by
LPS
Corbett et al., J Exp Med 1995
:
Although
TNF+LPS induce iNOS expression and
inhibit insulin secretion by intact islets, this combination does not induce the expression of iNOS by beta or alpha cells purified by fluorescence activated cell sorting ( Facs ) ... Evidence suggests that
TNF+LPS inhibit
insulin secretion from islets by stimulating the release of IL-1 which subsequently induces the expression of iNOS by beta cells ... The IL-1 receptor antagonist protein completely prevents
TNF+LPS induced inhibition of
insulin secretion and attenuates nitrite formation from islets, and neutralization of IL-1 with antisera specific for IL-1 alpha and IL-1 beta attenuates TNF+LPS induced nitrite formation by islets ... Local release of IL-1 within islets appears to be required for
TNF+LPS induced inhibition of
insulin secretion because TNF+LPS do not stimulate nitrite formation from islets physically separated into individual cells
Bundz et al., Shock 1995
:
LPS reduced plasma
insulin ( 54 % ), and increased glucagon ( 270 % ), corticosterone ( 180 % ), and tumor necrosis factor concentrations in plasma ( peak 3200-4600 pg/mL at 90 min ), with no modification by NAL pretreatment
Leeper-Woodford et al., Am J Physiol 1997
:
We monitored the
effects of
LPS and epinephrine on TNF and
insulin activity of isolated Wistar-Furth rat islets ( pancreas digested with collagenase, islets isolated using Ficoll gradients ; n = 4 islet populations, each with 632 +/- 11 islets/2.5 ml culture medium )
Arnush et al., J Clin Invest 1998
:
Inhibition of iNOS activity by aminoguanidine also attenuates TNF +
LPS + IFN-gamma induced
inhibition of
insulin secretion by human islets