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CCL2 — IFNG

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Oh et al., J Neurovirol 1999 : IFN-gamma induced the expression of IP-10, but not of IL-8, MCP-1 or RANTES
Tomura et al., Int J Mol Med 1999 : In contrast, another inducible gene expression of monocyte chemotactic protein-1 ( a CC chemokine ) and the activation of the transcriptional factor ( FcRFgamma ) bound to the gamma response region were similarly or less abundantly induced by IFNgamma treatment in PMA- or RA-differentiated U937 cells, indicating that increased IP-10 mRNA induction was not due to the augmented ability of the cells to respond to the presence of IFNgamma
Mohammed et al., Am J Respir Crit Care Med 1999 : IFN-gamma enhanced the BCG mediated MIP-1alpha and MCP-1 expression in a concentration dependent manner
Winsor et al., J Interferon Cytokine Res 2000 : Both IFN-gamma and IL-4 enhanced MCP-1 mRNA levels but with different kinetics ... IFN-gamma stimulated a transient increase in MCP-1 mRNA levels, which peaked at 2 h, whereas IL-4 stimulated MCP-1 mRNA levels were markedly increased at 1 h and remained elevated at all time points studied
Narumi et al., Cytokine 2000 : On the other hand, JE/MCP-1 mRNA expression was detected only in non-parenchymal cells in response to TNF-alpha and IL-1beta, but not in response to IFN-gamma
Li et al., J Oral Pathol Med 2000 : The kinetics of IFN-gamma induced MCP-1 production were similar for both cell types, peaking around 72 h
Matikainen et al., Virology 2000 : IFN-alpha or IFN-gamma were found to directly enhance MCP-1 , MCP-3, and IP-10 mRNA expression
Zhou et al., FASEB J 2001 (Astrocytoma) : Regulation of monocyte chemoattractant protein (MCP)-1 transcription by interferon-gamma (IFN-gamma) in human astrocytoma cells : postinduction refractory state of the gene, governed by its upstream elements
Giustizieri et al., J Allergy Clin Immunol 2001 (Dermatitis, Atopic...) : MCP-1 and IP-10 were potently induced by IFN-gamma , whereas IL-8 and RANTES were preferentially upregulated by TNF-alpha and, to a lesser extent, by IFN-gamma
Robson et al., J Immunol 2001 : Stimulation of cultured human peritoneal mesothelial cells with IFN-gamma ( 1-100 U/ml ) alone or in combination with IL-1beta ( 100 pg/ml ) or TNF-alpha ( 1000 pg/ml ) resulted in significant up-regulation of monocyte chemoattractant protein-1 and RANTES protein secretion
Andoh et al., Clin Exp Immunol 2001 : IL-17 and IFN-gamma synergistically increased IL-8 and MCP-1 secretion and mRNA abundance
Darville et al., Infect Immun 2001 (Chlamydia Infections...) : Inhibition of the MCP-1 response in C3H mice increased their later T-cell production of IFN-gamma but decreased their early IFN-gamma response and had no effect on the course or outcome of infection
Takaya et al., Scand J Gastroenterol 2002 : IL-17 and IFN-gamma synergistically increased IL-8 secretion and additively enhanced MCP-1 secretion
Laudes et al., J Immunol 2002 : Although LPS or IFN-gamma alone induced some release of MCP-1 and MIP-2, pre-exposure of these monolayers to LPS or IFN-gamma, followed by addition of C5a, resulted in synergistic production of MIP-2 and MCP-1
Häusler et al., Eur J Neurosci 2002 (Encephalitis...) : While amounts of TNFalpha and IL-6 remained nearly unchanged, IFNgamma enhanced the production of IL-12, MCP-1 and RANTES, but attenuated that of KC, MIP-1alpha and MIP-2
Lisignoli et al., Cytokine 2002 (Arthritis) : IFN-gamma significantly down-regulated IL-8 and up-regulated MCP-1 produced by OB from all patients tested, whereas it did not affect the other chemokines analysed ... Moreover, IFN-gamma reduced IL-1beta stimulated IL-8 production but significantly increased both MCP-1 and RANTES ... Interestingly, IL-6 significantly downregulated IFN-gamma induced MCP-1 production, that was significantly lower in OA compared to RA patients
Futagami et al., Gut 2003 (Gastritis...) : Media stimulated IFN-gamma but not IL-4 secretion from peripheral T cells, while MCP-1 stimulated IL-4 but not IFN-gamma secretion
Bosco et al., J Immunol 2004 : Hypoxia also inhibited, in a time dependent fashion, MCP-1 up-regulation by IFN-gamma and LPS
Del Rio et al., J Immunol 2004 : The production of both IL-12 and CCL2 was increased after neutrophil activation with IFN-gamma
Jeon et al., Biochem Biophys Res Commun 2005 : Expression of monocyte chemotactic protein-1 and interferon-gamma inducible protein-10 mRNA in response to IFN-gamma was significantly suppressed in the presence of NDGA, as was tyrosine-phosphorylation of JAK and STAT
Pechkovsky et al., Respir Res 2005 : Treatment of AEC-II with proinflammatory cytokines up-regulated both CCL2 mRNA expression and release of immunoreactive CCL2, whereas IFN-gamma had no effect on CCL2 release
Venkatesan et al., Cell Signal 2006 : Interferon-gamma (IFN-gamma) present in the microenvironment of glomerulus acts on mesangial cells to induce local production of MCP-1 ... The mechanism by which IFN-gamma stimulates expression of MCP-1 is not clear ... We therefore examined the role of PI 3 kinase signaling in regulating the IFN-gamma induced MCP-1 expression in mesangial cells ... Expression of dominant negative Akt kinase inhibited serine phosphorylation of STAT1alpha, without any effect on its tyrosine phosphorylation, and decreased IFN-gamma induced expression of MCP-1 ... Dominant negative PKCepsilon also abrogated MAPK activity, resulting in decrease in IFN-gamma induced MCP-1 expression
Song et al., Yao Xue Xue Bao 2005 (Dermatitis) : The enhancing effects of histamine and IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine ( 1 and 10 micromol x L ( -1 ) ) in DF and HaCaT cells
Chizzolini et al., Arthritis Res Ther 2006 (Inflammation...) : Thus, Th1 and Th2 cells preferentially induced production of IFN-gamma inducible protein ( IP ) -10 and IL-8, respectively, whereas monocyte chemoattractant protein (MCP)-1 was equally induced by both subsets at mRNA and protein levels
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis ... The IFN-gamma induced expression of MCP-1 in macrophages was attenuated by inhibitors of phosphoinositide-3-kinase (PI3K), casein kinase 2 ( CK2 ), and Janus kinase (JAK)-2 ... The IFN-gamma induced activity of the MCP-1 gene promoter and an artificial promoter containing STAT1 responsive elements was inhibited by expression of dominant negative forms of JAK-1 and -2, STAT1, CK2, and AKT
Cheng et al., J Clin Invest 2007 (Atherosclerosis...) : One week of shear stress alterations induced expression of IFN-gamma-inducible protein-10 ( IP-10 ) exclusively in the LSS region, whereas monocyte chemoattractant protein-1 ( MCP-1 ) and the mouse homolog of growth regulated oncogene alpha ( GRO-alpha ) were equally upregulated in both LSS and OSS regions
Yoshimura et al., J Immunol 2007 : Activation of neutrophils with LPS, lipoteichoic acid, or N-palmitoyl-S- [ 2,3-bis ( palmitoyloxy ) - ( 2RS ) -propyl ] - [ R ] -Cys- [ S ] -Ser- [ S ] -Lys did not induce significant MCP-1 production and release ; however, the Th1 cytokine IFN-gamma dramatically up-regulated MCP-1 production in cells activated with each TLR ligand
Liebler et al., Mediators Inflamm 1994 : In contrast, stimulation with IFN-gamma resulted in a dose dependent increase in MCP-1 protein and mRNA expression ... Simultaneous stimulation with IFN-gamma and IL-1beta or TNF-alpha resulted in no further increase in MCP-1 production ... It is concluded that IFN-gamma , primarily a product of T ( H ) 1 T lymphocytes, stimulates the expression of MCP-1 by monocytes
Hedman et al., Clin Exp Immunol 2008 (Diabetes Mellitus, Type 1) : The percentages of CD4 ( + ) cells expressing CXC chemokine receptor 3 (CXCR3), CXCR6 and CCR5, and the secretion of interferon-gamma induced protein-10, monocyte chemoattractant protein-1 , macrophage inflammatory protein (MIP)-1alpha and MIP-1beta was lower among diabetics
Machado et al., Microbes Infect 2008 : Interestingly, T. cruzi infected NOS2-deficient CMs produced significantly higher levels of CCL2 , CCL4, CCL5 and CXL2 in the presence of IFN-gamma and TNF
Lee et al., J Immunol 2008 (Encephalitis) : The inhibitory effects of 15d-PGJ ( 2 ) on MCP-1 resulted from its actions on the transcription factors, AP-1 and specificity protein-1, which play key roles in IFN-gamma induced MCP-1 expression in astrocytes
Strassheim et al., J Immunol 2009 : We found that activation of STAT1 was critical for IFN-gamma induced MCP-1 production and demonstrated that iloprost inhibited STAT1 activation by several actions as follows : 1 ) iloprost inhibited the phosphorylation of STAT1-S727 in the transactivation domain, thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1 ; 2 ) iloprost selectively inhibited activation of JAK2 but not JAK1, both responsible for activation of STAT1 via phosphorylation of STAT1-Y701, resulting in reduced nuclear recruitment and activation of STAT1 ; and 3 ) SOCS-1, which normally terminates IFN-gamma signaling, was not involved in iloprost mediated inhibition of STAT1, indicating divergence from the classical pathway for terminating IFN-gamma signaling
Goodyear et al., J Immunol 2010 (Burkholderia Infections...) : Production of IL-12 and IFN-gamma in the lungs after B. mallei infection was significantly impaired in both MCP-1 ( -/- ) and CCR2 ( -/- ) mice, whereas treatment of CCR2 ( -/- ) mice with rIFN-gamma restored protection against lethal challenge with B. mallei
Palus et al., Journal of neuroinflammation 2013 (Disease Resistance...) : These two strains also differed in the expression of key cytokines/chemokines, particularly interferon gamma induced protein 10 ( IP-10/CXCL10 ) and monocyte chemotactic protein-1 ( MCP-1/CCL2 ) in the brain
Musso et al., Blood 1995 : On the contrary, IFN-gamma by itself induced MCAF and did not affect the LIF induced MCAF
Leonard et al., Adv Exp Med Biol 1993 : In order of increasing effect, IL-2 + IFN gamma , IL-1 alpha, and LPS caused monocyte secretion of MCP-1
Brown et al., Am J Pathol 1994 : Differential regulation of monocyte chemoattractant protein-1 and interleukin-8 in response to interferon-gamma ... IFN-gamma , in combination with low doses of IL-1 alpha, resulted in a synergistic increase in MCP-1 generation by HLE
Ohmori et al., J Immunol 1994 : IFN-gamma selectively inhibits lipopolysaccharide-inducible JE/monocyte chemoattractant protein-1 and KC/GRO/melanoma growth stimulating activity gene expression in mouse peritoneal macrophages
Seitz et al., J Immunol 1994 (Arthritis, Rheumatoid...) : The constitutive or IL-1 beta stimulated release of MCP-1 , by contrast, was markedly enhanced by IL-4 and IFN-gamma
Van Damme et al., J Immunol 1994 : In connective tissue cells, IL-1 beta was the best inducer of MCP-1 , but IFN-gamma was a superior inducer of MCP-2
Grandaliano et al., J Lab Clin Med 1994 : These data demonstrate that human mesangial cells synthesize and release at least three different forms of MCP-1 and that IFN-gamma and other cytokines regulate the secretion of MCP-1
Satriano et al., J Immunol 1993 : Regulation of monocyte chemoattractant protein-1 and macrophage colony stimulating factor-1 by IFN-gamma , tumor necrosis factor-alpha, IgG aggregates, and cAMP in mouse mesangial cells
Hachicha et al., Arthritis Rheum 1993 : These studies demonstrate that the MCP-1 gene is regulated by TNF alpha and IFN gamma in type B synoviocytes and indicate that these cells may play an important role in the recruitment of inflammatory cells to the rheumatoid synovial environment, via the production of novel chemotactic cytokines such as MCP-1
Meda et al., J Immunol 1996 : Beta-amyloid ( 25-35 ) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells
Elner et al., Invest Ophthalmol Vis Sci 1997 : IFN-gamma induced dose dependent increases in HRPE MCP-1 , but not IL-8, IFN-gamma potentiated IL-1 beta and TNF-alpha induced MCP-1 production, but showed little modulation of IL-1 beta and TNF-alpha induced IL-8 production ... IFN-gamma alone induces HRPE MCP-1 , albeit to a lesser extent than would IL-1 beta or TNF-alpha, and potentiates IL-1 beta- and TNF-alpha induced HRPE MCP-1
Tangirala et al., J Biol Chem 1997 : However, interferon gamma inhibited MCP-1 binding by 60 % at 48 h
Goebeler et al., J Invest Dermatol 1997 : The chemokine repertoires of HDMECs and HMEC-1 were compared to those of human umbilical vein endothelium and found to be rather similar with the important exception that IFN-gamma and IL-4 up-regulated MCP-1 only in macrovascular endothelium
Boorstein et al., Curr Eye Res 1997 : IL-10 alone did not induce MCP-1 or IL-8 secretion or steady-state mRNA expression, nor modulate IL-1 beta-, TNF-alpha- or IFN-gamma induced IL-8 or MCP-1
Badolato et al., Blood 1997 (Inflammation) : In addition, IL-8 and MCP-1 induction by IL-15 is differently regulated by interferon-gamma (IFN-gamma) and IL-4
Lahrtz et al., Eur J Immunol 1997 (Meningitis, Viral) : To identify the chemotactic signals attracting the cells to the site of infection in the meninges, we measured the levels of two CXC chemokines, interferon-gamma (IFN-gamma) inducible protein (IP)-10 and monokine induced by IFN-gamma , four CC chemokines, monocyte chemotactic protein (MCP)-1 , RANTES, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, as well as the cytokines interleukin (IL)-15 and IL-16 in the cerebrospinal fluid (CSF) of patients suffering from viral meningitis
Elner et al., Exp Eye Res 1997 : Dose- and time dependent RPE cell MCP-1 secretion was also observed following IL-1 beta > TNF-alpha > IFN-gamma stimulation, with an average of 4 % of the total MCP-1 retained within RPE
Douglas et al., Immunology 1997 : Results from this study indicate that soluble, heparin-like GAGs can block IFN-gamma dependent up-regulation of MCP-1 production by cultured endothelial cells, and can also antagonize the leucocyte activating and migration promoting properties of pre existing MCP-1
Polentarutti et al., Eur J Immunol 1998 : Under the same conditions, as expected, IFN-gamma augmented monocyte chemotactic protein-1 expression in the same cell preparations
Warhurst et al., Gut 1998 : These cells showed no significant expression of the beta chemokines RANTES ( regulated upon activation T cell expressed and secreted ), MIP-1 alpha ( macrophage inflammatory protein 1 alpha ), and MCP-1 ( monocyte chemotactic protein 1 ) under these conditions, but IFN-gamma in combination with TNF-alpha caused a dose dependent induction of RANTES and MCP-1 secretion
Zhou et al., J Immunol 1998 (Astrocytoma) : We characterized regulation of the human monocyte chemoattractant protein-1 ( hMCP-1 ) gene by IFN-gamma in astrocytoma cells, because astroglial cells express chemokines in several central nervous system inflammatory states
Bauermeister et al., Nephrol Dial Transplant 1998 (Peritonitis) : LPS anergy for MCP-1 was still seen in PM after 10 days in culture, and IFN-gamma treatment again induced a significant rise in MCP-1 synthesis
Valente et al., J Immunol 1998 : A complex element regulates IFN-gamma stimulated monocyte chemoattractant protein-1 gene transcription ... Nuclear run-on and stability studies demonstrated that IFN-gamma stimulated MCP-1 transcription and did not enhance mRNA stabilization ... These studies establish a mechanism for IFN-gamma stimulated MCP-1 expression and identify a complex element that regulates MCP-1 gene transcription
Mohammed et al., J Infect Dis 1998 (Heart Failure...) : Reverse transcription-polymerase chain reaction studies confirmed that both BCG and IFN-gamma induced MIP-1alpha and MCP-1 expression in mesothelial cells, demonstrating that mesothelial cell derived C-C chemokines play a biologically important role in the recruitment of mononuclear cells to the pleural space
Haupt et al., Infection 1998 (Peritonitis) : IFN-gamma did not affect LPS induced TNF-alpha and MCP-1 production, but increased baseline MCP-1 production
van der Velden et al., Eur Cytokine Netw 1998 : Interleukin-1beta and interferon-gamma differentially regulate release of monocyte chemotactic protein-1 and interleukin-8 by human bronchial epithelial cells ... IFN-gamma greatly increased MCP-1 release, which was accompanied by increased expression of MCP-1 mRNA and an increased monocyte chemotactic potential ... Our results indicate that IFN-gamma and IL-1beta differentially regulate the MCP-1 and IL-8 release by human bronchial epithelial cells