◀ Back to IFNG

HSPG2 — IFNG

Text-mined interactions from Literome

Chang et al., Mol Pharmacol 2004 : IFN-gamma induced tyrosine phosphorylation of phospholipase C (PLC)-gamma was inhibited by AG 490 ( a JAK inhibitor ), and the association between JAK1/2 and PLC-gamma was increased after IFN-gamma treatment, indicating the activation of PLC-gamma via JAK1/2 phosphorylation ... These results confirmed that IFN-gamma activated PLC-gamma via JAK1/2 phosphorylation to induce PKC, c-Src, STAT1 activation, and ICAM-1 expression
von Knethen et al., Antioxid Redox Signal 2005 : These results suggest that IFNgamma causes PC-PLC stimulation, diacylglycerol release, Ca2+ influx, and concomitant PKC alpha activation, which subsequently depletes PKC alpha
Berman et al., Exp Cell Res 1989 (Fibrosarcoma) : In H12 cells, dbcAMP and PLC enhance the IFN-gamma induction of HLA-DR, but do not induce in the absence of INF-gamma
Sharma et al., J Biol Chem 1998 (Neovascularization, Pathologic) : We found that IFN-gamma rapidly and efficiently blocked perlecan gene expression with concurrent growth suppression, a phenomenon that was independent of a functional p21 ( WAF1/CIP1 ) ... Thus, the IFN-gamma mediated transcriptional repression of perlecan may represent a novel antitumoral effect of this cytokine through which it eliminates a powerful angiogenic stimulus