Gene interactions and pathways from curated databases and text-mining

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IFNG — TNFRSF1A

Text-mined interactions from Literome

Horie et al., Exp Hematol 1999 (Leukemia, Myeloid, Acute) : In conclusion, TNF induced apoptosis was mediated preferentially by TNFR1 , and the anti-apoptotic effect of IFN-gamma was result from up-regulated TNFR2 in EoL-1 cell line
Wong et al., J Immunol 1992 : We have found that anti-TNF-R1 , but not anti-TNF-R2, Ab trigger antiviral activity in human hepatoma Hep-G2 cells and enhance the antiviral activity of IFN-gamma in human lung fibroblast A549 cells
Buntinx et al., J Neurosci Res 2004 : In addition to direct cytotoxic effects, IFN-gamma and TNF-alpha also enhance the expression of Fas, TNFR1 , and MHC class I molecules in both cell lines
Bode et al., J Biol Chem 2006 (Genetic Predisposition to Disease...) : However, IFNgamma up-regulated TNFR1 expression and amplified TNFalpha induced protein leakage
Solarewicz-Madejek et al., Clin Exp Allergy 2009 (Asthma...) : IFN-gamma and TNF-alpha up-regulated TNFR1 , TNFR2, Fas and membrane FasL on SMC
Agresti et al., Eur J Neurosci 1998 : Following the exposure of oligodendrocytes to IFN-gamma, TNF-R1 expression was transcriptionally induced by the binding of signal transducer and activator of transcription ( STAT-1 ) homodimers to the IFN-gamma activated site ( GAS ) present in the gene promoter
Chan et al., J Immunol 1999 : Collectively, these findings support the involvement of p46 JNK/SAPK and its upstream kinases in regulating the induction of iNOS following ligation of the TNF-alpha receptor CD120a ( p55 ) in the presence of IFN-gamma