Han et al., International journal of molecular sciences 2012
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Shikonin treatment alone could slightly inhibit the phosphorylation of ERK1/2 in leukemia cells, and the inhibitory effect on ERK1/2 was significantly augmented by Nec-1 Zhang et al., Neurotox Res 2013
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Further, we found glutamate treatment increased phosphorylated ERK1/2 level, but the specific necroptosis inhibitor Necrostatin-1 (Nec-1) significantly inhibited the phosphorylation of ERK1 ( P44 ) at 5, 10, and 15 min after glutamate treatment ; the phosphorylation of ERK2 ( P42 ) level was also markedly reduced by Nec-1 at 10 min after glutamate treatment