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EPHB2 — PRKCA

Text-mined interactions from Literome

Cheng et al., J Biol Chem 2001 : Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain ... PKC-alpha mediated mainly the early ERK1/2 activation, whereas PKC-epsilon was involved in the sustained ERK1/2 activation
Lo et al., J Cell Physiol 2001 : Involvement of PKCalpha in mediating ERK activation was further confirmed by the inhibition of ERK and the subsequent Egr-1 gene induction with antisense oligonucleotides to PKCalpha
Besson et al., Oncogene 2001 (Brain Neoplasms...) : Herein, we report that specific PKC isoforms are able to differentially activate extracellular-signal regulated kinase ( ERK ) in distinct cellular locations : while PKC alpha induces the activation of nuclear ERK , PKC epsilon induces the activation of ERK at focal adhesions
Braz et al., J Cell Biol 2002 (Cardiomyopathy, Hypertrophic) : A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal regulated kinase1/2 ( ERK1/2 ), that dominant negative PKC alpha inhibited PMA induced ERK1/2 activation, and that dominant negative MEK1 ( up-stream of ERK1/2 ) inhibited wild-type PKC alpha induced hypertrophic growth
Pecherskaya et al., Alcohol Clin Exp Res 2002 (Alcoholism) : Recently, our laboratory reported that IGF-I activates protein kinase-C (PKC)-alpha and that PKC-alpha activity is required for IGF-I dependent activation of Erk1/Erk2 and IGF-I dependent protein synthesis
Nowak et al., J Biol Chem 2002 : Furthermore, inhibition of PKC-alpha did not prevent cisplatin induced ERK1/2 activation
Choe et al., J Neurochem 2002 : Specific inhibition of PKCalpha with safingol blocked the phosphorylation of ERK induced by TPA
Adayev et al., Biochim Biophys Acta 2003 : ERK dependent activation of only PKCalpha was observed in immunoprecipitates obtained from 5-HT(1A) agonist treated HN2-5 cells
Acconcia et al., IUBMB Life 2003 : At the present meagre information is available for the role played by the rapid hormone action mechanism ( s ) ( i.e., activation of ERK , PI(3)K, PKC-alpha ) in modulating E2-induced gene promoter activity
Pan et al., J Cell Physiol 2005 (Cardiomegaly) : Stretch stimulated phosphorylation of MEK1/ERK1/2 and MKK4/JNK was inhibited by overexpression of DN PKCalpha and delta, and that of MKK3/p38 inhibited by DN PKCdelta ... The phosphorylation of ERK and JNK induced by overexpression of WT PKCalpha , and the phosphorylation of p38 induced by WT PKCdelta, were regulated by Rho GTPases
Seo et al., Exp Mol Med 2004 : PKCalpha induces differentiation through ERK1/2 phosphorylation in mouse keratinocytes
Khundmiri et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Parathyroid hormone mediated regulation of Na+-K+-ATPase requires ERK dependent translocation of protein kinase Calpha ... Inhibition of PKCalpha expression by siRNA did not inhibit PTH mediated ERK activation but significantly reduced PTH mediated phosphorylation of the Na+-K+-ATPase alpha1 subunit ... We conclude that PTH stimulates Na+-K+-ATPase phosphorylation and decreases the activity of Na+-K+-ATPase by ERK dependent activation of PKCalpha
Rucci et al., J Cell Sci 2005 (Bone Resorption) : In contrast, PKCalpha was involved in ERK1/2 activation because inhibition of its activity prevented ERK1/2 phosphorylation ... The alphaVbeta3/PKCalpha complex formation was fully dependent upon the intracellular calcium concentration ( [ Ca2+ ] i ), and the use of the intracellular Ca2+ chelator 1,2-bis ( o-amino-phenoxy ) ethane-N, N,N ', N'-tetraaceticacidtetra ( acetoxymethyl ) ester ( BAPTA-AM ) also inhibited PKCalpha translocation and ERK1/2 phosphorylation
Maniar et al., Mol Cell Biochem 2005 : Previously, the laboratory has reported that IGF1 activates PKC alpha in adult rat cardiomyocytes, and that PKC alpha activity is required for IGF1 dependent Erk/Erk2 activity and protein synthesis
Li et al., Cell Immunol 2005 (MAP Kinase Signaling System) : PKCalpha , betaI, and betaII were all involved in activation of JNK, MEKK2, and ERK5 , with differential relative contributions of each isoform to specific MAPK pathway components
Momberger et al., Matrix Biol 2006 (Calcium Signaling...) : PKCalpha translocated from cytosol to membrane and triggered the phosphorylation of ERK1/2
Marjuki et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha mediated activation of ERK signaling
Anfuso et al., J Lipid Res 2007 (MAP Kinase Signaling System) : Our findings indicate that a sequential activation of PKCalpha contributes to endothelial ERK1/2 and cPLA(2) phosphorylation induced by either soluble factors or direct cell-to-cell contact, and that the PKCalpha-cPLA(2) pathway appears to play a key role in the early phase of EC-pericyte interactions regulating blood retina or blood-brain barrier maturation
Kwon et al., J Dermatol Sci 2007 (MAP Kinase Signaling System) : Over-expression of PKCalpha markedly induced the IL-6 expression and p42/44 ERK activation
Khundmiri et al., American journal of physiology. Renal physiology 2008 : Parathyroid hormone (PTH) inhibits Na+-K+-ATPase activity by serine phosphorylation of the alpha1-subunit through ERK dependent phosphorylation and translocation of protein kinase Calpha (PKCalpha)
Gutiérrez-Venegas et al., Toxicol In Vitro 2010 : Activation of ERK1/2 by protein kinase C-alpha in response to hydrogen peroxide induced cell death in human gingival fibroblasts
Tiedemann et al., J Biol Chem 2009 (MAP Kinase Signaling System) : Inhibition of protein kinase Calpha using Gö6976 prevented both ERK1/2 phosphorylation and osteoclast formation in response to MDA-MB-231 derived factors
Francis et al., Mol Cancer Res 2009 (Bile Duct Neoplasms...) : Silencing of PKCalpha prevented RAMH inhibition of Mz-ChA-1 cell growth and ablated RAMH effects on ERK1/2 phosphorylation
Yan et al., J Cell Biochem 2010 (Cardiomegaly) : The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting PKC-alpha dependent ERK1/2 and PI3K/AKT signaling
Debata et al., Biochem Biophys Res Commun 2010 : Employing PKCalpha and Erk mutants we next demonstrated that Erk causes direct phosphorylation and activation of PKCalpha
Traub et al., J Biol Chem 1997 : Scrambled PKC-epsilon oligonucleotides and antisense PKC-alpha and PKC-zeta oligonucleotides had no effect on ERK1/2 activity