We have a suspicion that you are an automated web bot software, not a real user.
To keep our site fast for other users, we have slowed down this page.
The slowdown will gradually disappear.
If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu.
Also note that all data for hgGeneGraph can be obtained through our public MySQL server and
all our software source code is available and can be installed locally onto your own computer.
If you are unsure how to use these resources, do not hesitate to contact us.
Richard et al., J Biol Chem 1999
(Anoxia) :
p42/p44 mitogen activated protein kinases phosphorylate hypoxia-inducible factor 1alpha ( HIF-1alpha ) and enhance the transcriptional activity of HIF-1 Fradette et al., Curr Drug Metab 2004
(Anoxia...) :
The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1, binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Li et al., Clin Cancer Res 2004
(Anoxia...) :
Additional analyses using LY294002 and U0126 indicated that the increase in hypoxia-inducible factor 1 (HIF-1)alpha protein level was highly dependent on phosphatidylinositol 3'-kinase and p42/p44 mitogen activated protein kinase activities in hypoxic MDA-MB-468 cells