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F2R — NFKB1

Text-mined interactions from Literome

Bretschneider et al., Br J Pharmacol 1999 : Activation of NFkappaB via either PAR-1 or PAR-2 does not predict mitogenesis
Rahman et al., Circ Res 2002 : Cotransfection of RGS3T, a regulator of G-protein signaling that inhibits Galpha ( q ), or alpha-transducin ( Galpha ( t ) ), a scavenger of the Gbetagamma, markedly decreased NF-kappaB activity induced by PAR-1 activation ... These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt
Tantivejkul et al., J Cell Biochem 2005 (Prostatic Neoplasms) : PAR1 mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL dependent mechanism ... Inhibition of p38 and ERK1/2 by SB-203589 and PD-098059, respectively, did not abrogate NFkappaB activity, suggesting an independent induction of NFkappaB by PAR1 stimulation
Syeda et al., J Biol Chem 2006 : Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK
Lin et al., Arterioscler Thromb Vasc Biol 2006 : Conversely, small interfering RNA mediated knockdown of KLF2 increases PAR-1 expression and thrombin mediated induction of NF-kappaB activation
Gorbacheva et al., Neuroscience 2010 : Then we investigated whether the binding of APC to EPCR/PAR-1 is required to control NF-kappaB activation
Fujimoto et al., BMC cancer 2010 (Neoplasm Invasiveness...) : We have shown that activation of NF-kappaB and EGFR phosphorylation initially were triggered by the activation of PAR1 with alpha-thrombin