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HSP90AA1 — NFKB1
Pathways - manually collected, often from reviews:
-
WikiPathways EBV LMP1 signaling:
Complex of IKBKG-CHUK-IKBKB-HSP90AA1
→
Complex of NFKBIA-NFKB1-RELA
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lewis et al., J Biol Chem 2000
:
These data indicate that
Hsp90 plays an important role in TNF mediated
NF-kappaB activation by modulating the stability and solubility of RIP
Tago et al., Life Sci 2004
:
Hsp90 inhibitors
attenuate effect of dexamethasone on activated
NF-kappaB and AP-1 ... Both tumor necrosis factor-alpha activated
NF-kappaB and phorbol ester activated AP-1 were
inhibited by Dex and
Hsp90 inhibitors alone ... These results suggest that
Hsp90 inhibitor itself
inhibits the activation of
NF-kappaB and AP-1, however, impedes Dex induced inhibition of IL-1beta induction by attenuating Dex mediated activation of GR and inhibition of the proinflammatory transcription factors
Yan et al., Autophagy 2007
(Cell Transformation, Viral) :
We recently found that specific inhibition of
Hsp90 by geldanamycin ( GA )
results in autophagic degradation of IKK and
NFkappaB inducing kinase (NIK) , an upstream kinase of IKK, and inactivation of NFkappaB in various cell lines ... Here, we further report that GA inhibition of
Hsp90 also
led to IKK autophagic degradation and
NFkappaB inhibition in both HTLV transformed T cells and ATL derived cell lines
Kim et al., Mol Cancer Res 2008
(Glioma) :
Here, we report that the
Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced
nuclear factor-kappaB (NF-kappaB) activation is
mediated by IkappaB kinase, which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation
Myung et al., J Pharmacol Exp Ther 2009
:
These results demonstrate that the
Hsp90 inhibitor induces HSC apoptosis via a sphingomyelinase- and
NFkappaB dependent mechanism