Brown et al., Ann Clin Lab Sci 2006
(Neoplasms, Squamous Cell...) :
Because the mammalian target of the rapamycin (mTOR) pathway contributes to the activation of NF-kappaB through immunophilin/mTOR signaling , we investigated : ( a ) the immunohistochemical expression and state of activation and potential clinical significance of components of the mTOR signal transduction pathway in SCCT patients ( morphoproteomics ) ; and ( b ) the inhibitory effects of rapamycin on the growth and state of activation of mTOR in 2 HNSCC cell lines ( pharmacoproteomics )
Dan et al., Genes Dev 2008
(Prostatic Neoplasms) :
Akt dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK ... The mTOR associated protein Raptor is required for the ability of Akt to induce NF-kappaB activity
Shen et al., International journal of clinical and experimental pathology 2010
(Carcinoma, Endometrioid...) :
mTORC1 and mTORC2 phosphorylatively regulate their respective downstream effectors p70S6K/4EBP1 , and Akt