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ARF1 — JUN
Text-mined interactions from Literome
Kim et al., J Biol Chem 2003
:
In addition,
ARF4 mediated PLD2 activation
leads to dramatic activation of the transcription factor
activator protein 1 (AP-1) , and, importantly, ARF4 activity is required for EGF induced activation of cellular AP-1
Ameyar-Zazoua et al., Oncogene 2005
:
The
ARF promoter is
regulated specifically by
AP-1 heterodimers containing Fra-1 ... Conversely, inhibition of
c-Jun or Fra-1 protein levels
resulted in decreased
ARF expression ... Thus,
AP-1 heterodimers may
contribute to the regulation of
ARF expression upon oncogenic signaling
Lee et al., J Cell Biol 2008
:
Binding of cargo sorting signals to
AP-1 enhances its association with
ADP ribosylation factor 1-GTP
Suri et al., Methods Mol Biol 2008
:
AP-1 recruitment is
mediated by the GTPase
Arf1 , requires specific lipids, and cargo signals
Wonderlich et al., J Virol 2011
(HIV Infections) :
ADP ribosylation factor 1 activity is
required to recruit
AP-1 to the major histocompatibility complex class I ( MHC-I ) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1 infected primary T cells ... An
ARF-1 inhibitor
blocked the ability of Nef to recruit
AP-1 to the MHC-I cytoplasmic tail, and a dominant active ARF-1 mutant stabilized the Nef-MHC-I-AP-1 complex ... These data support a model in which Nef and
ARF-1 stabilize an interaction between MHC-I and
AP-1 to disrupt the presentation of HIV-1 epitopes to CTLs
Huser et al., Biochem J 2013
:
This localization depends on interaction of clathrin and the adaptor sequence in the amphiphysins and is sensitive to brefeldin A, which inhibits
Arf1 dependent
AP-1 recruitment
Canagarajah et al., Protein Sci 2013
:
Cargo binding by
AP-1 is
activated by the small GTPase
Arf1 , while AP-2 is activated by the phosphoinositide PI ( 4,5 ) P2
Le Borgne et al., J Cell Biol 1997
:
Using an in vitro assay that reconstitutes the
ARF-1 dependent translocation of cytosolic
AP-1 onto membranes of the TGN, we have previously reported that the MPRs are key components for the efficient recruitment of AP-1 ( Le Borgne, R., G. Griffiths, and B. Hoflack
West et al., J Cell Biol 1997
:
Surprisingly, however, neither PLD nor neomycin has any effect on the recruitment of AP-1 adaptors onto the TGN, even though
AP-1 recruitment is
ARF mediated
Ooi et al., J Cell Biol 1998
:
ARF1 controls the clathrin coat adaptor
AP-1 and the nonclathrin coat COPI, whereas Sar1p controls the nonclathrin coat COPII